{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:39:11Z","timestamp":1791967151513,"version":"4.3.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["K23DE025023"],"award-info":[{"award-number":["K23DE025023"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["U01DE029750"],"award-info":[{"award-number":["U01DE029750"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Compare the effectiveness of palatoplasty and pharyngoplasty procedures at resolving hypernasality in patients with 22q11.2 deletion syndrome (22q).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Metropolitan children's hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Fourteen patients with 22q presenting for management of velopharyngeal insufficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Palatoplasty or pharyngoplasty procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure<\/jats:title>\n                    <jats:p>Resolution of hypernasality 12 months postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both procedure groups had a mean preoperative velopharyngeal gap of 6.2\u2005mm during phonation. No patient who underwent palatoplasty achieved resolution of hypernasality; 1\/7 patients had worse hypernasality, 4\/7 had no change, and 2\/7 had improved hypernasality. In contrast, hypernasality was resolved in 6\/7 patients in the pharyngoplasty group, which was significantly (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.03) higher than the palatoplasty group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with 22q, palatoplasty procedures may be less effective than pharyngoplasty procedures at resolving hypernasality. This may be due to underlying anatomic or physiologic differences, such as increased pharyngeal depth and hypodynamic muscles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656241266365","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T05:57:31Z","timestamp":1721973451000},"page":"1616-1624","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Do Palatoplasty Procedures Resolve Hypernasality as Effectively as Pharyngoplasty Procedures in Patients with 22q11.2 Deletion Syndrome?"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-7275","authenticated-orcid":false,"given":"Jessica L.","family":"Williams","sequence":"first","affiliation":[{"name":"Phoenix Children's Hospital"},{"name":"Phoenix Children's Hospital"},{"name":"Program of Speech and Hearing Science, College of Health Solutions, Arizona State University, Tempe, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-9159","authenticated-orcid":false,"given":"Jamie L.","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences and Disorders, East Carolina University, Greenville, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinder J.","family":"Singh","sequence":"additional","affiliation":[{"name":"Phoenix Children's Hospital"},{"name":"Phoenix Children's Hospital"},{"name":"Mayo Clinic Arizona, Scottsdale"},{"name":"Department of Child Health, University of Arizona College of Medicine \u2013 Phoenix, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2173-923X","authenticated-orcid":false,"given":"Thomas J.","family":"Sitzman","sequence":"additional","affiliation":[{"name":"Phoenix Children's Hospital"},{"name":"Phoenix Children's Hospital"},{"name":"Mayo Clinic Arizona, Scottsdale"},{"name":"Department of Child Health, University of Arizona College of Medicine \u2013 Phoenix, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"GeneReviews\u00ae [Internet]","author":"McDonald-McGinn DM","year":"1999","unstructured":"McDonald-McGinn DM, Hain HS, Emanuel BS, et al. 22q11.2 Deletion syndrome. 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