{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:03:30Z","timestamp":1791299010897,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Nasoalveolar molding (NAM) can optimize aesthetic outcomes in patients with cleft lip and palate (CLP), particularly in those with wider clefts. However, its impact on long-term postoperative sequelae such as midface hypoplasia (MFH) remains unclear. This study analyzed cephalometric data to evaluate NAM's effect on MFH in patients with complete unilateral CLP (UCLP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Systematic Review and Meta Analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Included studies reported cephalometrics of patients\u2009\u2265\u20097 years old with repaired UCLP who underwent presurgical NAM versus no-NAM (control). Studies of bilateral cases or unoperated clefts were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Main outcomes were cephalometric angles (sella-nasion-A point (SNA), sella-nasion-B point (SNB), and A point-nasion-B point (ANB)) of patients treated with NAM vs. no-NAM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 2063 articles, three met inclusion criteria. Cephalometrics were reported for 171 patients (89 NAM, 82 no-NAM) at an average age of 8.5\u2009\u00b1\u20090.9 years. On pooled analysis, compared to the no-NAM cohort, the NAM cohort had insignificantly smaller SNA (78.8\u00b0\u00b11.5\u00b0 vs. 76.7\u00b0\u00b11.5\u00b0, p\u2009=\u20090.169), SNB (75.5\u00b0\u00b11.0\u00b0 vs. 75.5\u00b0\u00b11.0\u00b0, p\u2009=\u20090.954), and ANB (3.6\u00b0\u00b11.4\u00b0 vs. 1.23\u00b0\u00b11.2\u00b0, p\u2009=\u20090.089) angles. Upon meta-analysis, compared to the no-NAM cohort, the NAM cohort had significantly smaller SNA (Mean Difference (MD) \u22121.96 [\u22123.31 to \u22120.61], p\u2009=\u20090.005) and ANB angles (MD \u22122.22 [\u22123.20 to \u22121.24], p\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta-analysis revealed that patients with UCLP who underwent presurgical NAM had significantly smaller SNA and ANB angles, possibly indicating worse MFH. Before choosing NAM, clinicians should consider CLP severity, potential sagittal growth restrictions, and feasibility, particularly in low-resource settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656241286386","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T02:49:04Z","timestamp":1734058144000},"page":"1939-1946","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Presurgical Nasoalveolar Molding on Midface Growth in Unilateral Cleft Lip and Palate: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9078-7809","authenticated-orcid":false,"given":"T.","family":"Moshal","sequence":"first","affiliation":[{"name":"Keck School of Medicine, University of Southern California"},{"name":"Children's Hospital Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7843-583X","authenticated-orcid":false,"given":"I.","family":"Roohani","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, University of Southern California"},{"name":"Children's Hospital Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-2210","authenticated-orcid":false,"given":"M.","family":"Jolibois","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3336-0540","authenticated-orcid":false,"given":"S.","family":"Lasky","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, University of Southern California"},{"name":"Children's Hospital Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0088-2991","authenticated-orcid":false,"given":"A.","family":"Manasyan","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, University of Southern California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Naidu","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of USC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. C. O.","family":"Munabi","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Urata","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0030-1420","authenticated-orcid":false,"given":"J. A.","family":"Hammoudeh","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"W. P.","family":"Magee","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/CCIDE.S129598"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000007026"},{"issue":"10","key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/01.GOX.0000799404.34620.ab","article-title":"Incidence of orthognathic surgery in patients with repaired cleft lip and palate","volume":"9","author":"Jacob L","year":"2021","unstructured":"Jacob L, Fahradyan A, Paulson P, et al. Incidence of orthognathic surgery in patients with repaired cleft lip and palate. Plast Reconstr Surg Glob Open. 2021;9(10S):60\u201361.","journal-title":"Plast Reconstr Surg Glob Open."},{"issue":"4","key":"e_1_3_2_5_2","first-page":"314","article-title":"The Goslon Yardstick: A new system of assessing dental arch relationships in children with unilateral clefts of the lip and palate","volume":"24","author":"Mars M","year":"1987","unstructured":"Mars M, Plint DA, Houston WJ, Bergland O, Semb G. The Goslon Yardstick: A new system of assessing dental arch relationships in children with unilateral clefts of the lip and palate. Cleft Palate J. 1987;24(4):314\u2013322.","journal-title":"Cleft Palate J."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656221136325"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1597\/16-018"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1055665618757367"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000005356"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000007828"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2001_038_0582_absoca_2.0.co_2"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2002_039_0527_rbppfa_2.0.co_2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181d5132a"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2010.04.033"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-011-0601-4"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1597\/12-114"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1597\/04-077r.1"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1993_030_0175_rbcsad_2.3.co_2"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1597\/10-044"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000479979.83169.57"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656221116005"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/7.4.231"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31814fb711"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1998_035_0313_stdopa_2.3.co_2"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-30770-6_14"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004243"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05119-7"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4041\/kjod.2021.51.1.43"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000006943"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/ocr.12467"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000009960"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000007532"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656241286386","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10556656241286386","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656241286386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:21:23Z","timestamp":1777393283000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10556656241286386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1177\/10556656241286386"],"URL":"https:\/\/doi.org\/10.1177\/10556656241286386","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]}}}