{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:48:02Z","timestamp":1789480082972,"version":"build-2803163510"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Objective<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>Craniosynostosis, a condition marked by the premature fusion of one or more cranial sutures, exhibits diverse phenotypes. This study aims to advance the understanding of these phenotypes beyond the conventional 2-dimensional analysis by focusing on identifying indicators of increased intracranial pressure (ICP) such as bony thinning or irregularities in skull morphology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Methods<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>A retrospective review was conducted for all pediatric patients with midline craniosynostosis who presented to our tertiary academic center for evaluation. Control patients were carefully selected to match for age, sex, and weight. All computed tomography data were segmented in 3-dimensional Slicer and then delineated along with suture lines into occipital, parietal, and frontal segments. Main outcome measures included general skull shape (assessed via measures of flatness and surface area to volume ratio) and skull topography (analyzed via measures of bone thickness, surface variance, and surface standard deviation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Results and Conclusions<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>Forty-one patients with midline craniosynostoses were identified (22 metopic and 19 sagittal). Patients with sagittal craniosynostosis had significantly angulated frontal and occipital bones, reflective of the frontal bossing and occipital bulleting commonly seen in this population, and significantly flatter parietal bones, reflective of limited growth along with the transverse axis. Interestingly, evaluation of bone topography revealed that patients with sagittal craniosynostosis had significantly higher parietal bone surface variance, reflective of gyral impressions secondary to increased ICP. In contrast, patients with metopic craniosynostosis had statistically flatter frontal bones\u2014reflective of limited anterior brain growth caused by the fused metopic suture\u2014with minimal impacts to parietal or occipital bones.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656241297526","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:07:28Z","timestamp":1737331648000},"page":"38-48","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Craniosynostosis: Quantifying Differences in Skull Architecture"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1008-954X","authenticated-orcid":false,"given":"Jesse E.","family":"Menville","sequence":"first","affiliation":[{"name":"The Warren Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Shinde","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Collins","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Jiao","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah M.","family":"Persad-Paisley","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navya","family":"Baranwal","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert S.","family":"Woo","sequence":"additional","affiliation":[{"name":"The Warren Alpert Medical School of Brown University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"StatPearls","author":"Betances EM","year":"2023","unstructured":"Betances EM, Mendez MD, Das JM. Craniosynostosis. In: StatPearls. StatPearls Publishing; 2023. Accessed September 24, 2023. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544366\/"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.22373"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000056839.94034.47"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2010.235"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/2015.2.FOCUS155"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2016.04.006"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2539"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004374"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31905"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2007.08.008"},{"issue":"12","key":"e_1_3_3_12_2","article-title":"Syndromic craniosynostosis: a comprehensive review","volume":"15","author":"Katouni K","year":"2023","unstructured":"Katouni K, Nikolaou A, Mariolis T, Protogerou V, Chrysikos D, Theofilopoulou S, Filippou D. Syndromic craniosynostosis: a comprehensive review. Cureus. 2023;15(12):e50448. doi:https:\/\/doi.org\/10.7759\/cureus.50448","journal-title":"Cureus"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1320063"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000008976"},{"issue":"2","key":"e_1_3_3_15_2","first-page":"110","article-title":"Craniosynostosis\u2014recognition, clinical characteristics, and treatment","volume":"18","author":"Kajdic N","year":"2018","unstructured":"Kajdic N, Spazzapan P, Velnar T. Craniosynostosis\u2014recognition, clinical characteristics, and treatment. Bosn J Basic Med Sci. 2018;18(2):110-116. doi:https:\/\/doi.org\/10.17305\/bjbms.2017.2083","journal-title":"Bosn J Basic Med Sci"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3171\/2020.1.PEDS2051"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2016.06.007"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0339"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e31823aec1d"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10005-1233"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3171\/PED-08\/01\/025"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.10.021"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199610000-00007"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3171\/2021.6.PEDS21162"},{"key":"e_1_3_3_26_2","first-page":"1095","article-title":"Intracranial pressure, autoregulation, and cerebral perfusion in infants with nonsyndromic craniosynostosis at the time of surgical correction","volume":"12","author":"Hurth H","year":"2023","unstructured":"Hurth H, Zipfel J, Kerscher SR, Decker K, Haas-Lude K, Krimmel M, Neunhoeffer F, Schuhmann MU. Intracranial pressure, autoregulation, and cerebral perfusion in infants with nonsyndromic craniosynostosis at the time of surgical correction. Neurosurgery. 2023;12:1095-1103. Published online December 13, 2023. doi:https:\/\/doi.org\/10.1227\/neu.0000000000002797","journal-title":"Neurosurgery"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.41.4.829"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-004-1108-y"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00366148"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00271819"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.3340\/jkns.2016.59.3.242"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47622-7"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-012-1803-z"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000005034"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003422"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000008782"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000008745"},{"issue":"3","key":"e_1_3_3_38_2","article-title":"Craniometric measurements and surgical outcomes in trigonocephaly patients who underwent surgical treatment","volume":"13","author":"Ba\u015f NS","year":"2023","unstructured":"Ba\u015f NS, Ba\u015f S. Craniometric measurements and surgical outcomes in trigonocephaly patients who underwent surgical treatment. Cureus. 2023;13(3):e13676. doi:https:\/\/doi.org\/10.7759\/cureus.13676","journal-title":"Cureus"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3171\/2016.2.PEDS15524"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000006260"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2014.02.008"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1049\/htl.2017.0067"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11548-020-02301-0"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.3171\/2018.5.PEDS1876"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199209000-00003"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.57.3.0370"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00301758"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.0025"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000010797"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000008748"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-016-3143-x"},{"key":"e_1_3_3_52_2","volume-title":"StatPearls [Internet]","author":"Sharma S","year":"2023","unstructured":"Sharma S, Hashmi MF, Kumar A. Intracranial hypertension. In: StatPearls [Internet]. StatPearls Publishing; 2023. Accessed November 20, 2023. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507811\/"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1159\/000066311"},{"issue":"4","key":"e_1_3_3_54_2","first-page":"723","article-title":"Sensitivity of papilledema as a sign of increased intracranial pressure","volume":"10","author":"Krahulik D","year":"2023","unstructured":"Krahulik D, Hrabalek L, Blazek F, Halaj M, Slachta M, Klaskova E, Maresova K. Sensitivity of papilledema as a sign of increased intracranial pressure. Children (Basel). 2023;10(4):723. doi:https:\/\/doi.org\/10.3390\/children10040723","journal-title":"Children (Basel)"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656241297526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10556656241297526","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656241297526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:22:04Z","timestamp":1777393324000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10556656241297526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,19]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1177\/10556656241297526"],"URL":"https:\/\/doi.org\/10.1177\/10556656241297526","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,19]]}}}