{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:38:13Z","timestamp":1777523893570,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Background<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>Common congenital malformations known as orofacial clefts include cleft lip, cleft lip and palate, and cleft palate. They present significant public health challenges globally due to their medical, psychological, and socioeconomic impacts. Genetic and environmental factors mostly influence the genesis of nonsyndromic cleft lip with or without cleft palate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Methods<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>\n                      A meta-analysis was carried out to evaluate the association between\n                      <jats:italic toggle=\"yes\">IRF6<\/jats:italic>\n                      polymorphisms (rs2235371, rs2235373, and rs2235375) and NSCL\/P. PubMed, Google Scholar, Scopus, and Embase were systematically searched for relevant articles. Studies meeting predefined inclusion criteria included case-control designs, genotype data, and statistical measures (odds ratios, 95% confidence intervals). Seventeen research papers were chosen based on the Newcastle-Ottawa Scale criteria for worth evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Results<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>\n                      The meta-analysis included 1809 NSCL\/P cases and 3164 controls from diverse populations, including Chinese Han, Brazilian, South Indian, Northeast Chinese, Uyghur, Indonesian, Vietnamese, Mesoamerican, and Iranian groups. However, in our analysis, only specific\n                      <jats:italic toggle=\"yes\">IRF6<\/jats:italic>\n                      SNPs\u2014rs2235371 and rs2235373\u2014showed significant associations in the allelic and dominant models, respectively, while other SNPs, including rs2235375, showed no significant association. These findings underscore the genetic heterogeneity of NSCL\/P across various ethnic groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>\n                      This meta-analysis emphasizes the complex role of\n                      <jats:italic toggle=\"yes\">IRF6<\/jats:italic>\n                      polymorphisms in the genetic susceptibility to NSCL\/P. While significant associations were identified in several populations, the lack of association in others suggests that genetic factors contributing to NSCL\/P vary widely. Further research is needed to elucidate additional genetic determinants and their interfaces with environmental factors in the pathogenesis of NSCL\/P.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656241300841","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T03:08:10Z","timestamp":1732244890000},"page":"279-287","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic Variability of\n                    <i>IRF6<\/i>\n                    Polymorphisms in Non-Syndromic Cleft Lip\/Palate: A Meta-Analysis Across Diverse Populations"],"prefix":"10.1177","volume":"63","author":[{"given":"Jethendra Kumar","family":"Muruganantham","sequence":"first","affiliation":[{"name":"Chettinad Academy of Research and Education"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9307-5428","authenticated-orcid":false,"given":"Ramakrishnan","family":"Veerabathiran","sequence":"additional","affiliation":[{"name":"Chettinad Academy of Research and Education"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes14081603"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2013.12.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2002.610402.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01577.x"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000009591"},{"issue":"02","key":"e_1_3_3_7_2","first-page":"121","article-title":"Study of congenital malformations in central nervous system & gastro-intestinal tract","volume":"2","author":"Saiyad SS","unstructured":"Saiyad SS, Hrishikesh J. Study of congenital malformations in central nervous system & gastro-intestinal tract. 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RT-qPCR gene expression analysis on the Irf6 intron polymorphism in oral epithelium of nonsyndromic oral cleft risk of Deutero-Malay sub-race Indonesian. Journal of International Dental and Medical Research. 2020;13(2):491-496.","journal-title":"Journal of International Dental and Medical Research"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3180423cca"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes14111995"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-08164-9"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20689"},{"issue":"2","key":"e_1_3_3_24_2","first-page":"181","article-title":"Association of rs2013162 and rs2235375 polymorphisms in IRF6 gene with susceptibility to nonsyndromic cleft lip and palate","volume":"14","author":"Soleymani M","year":"2022","unstructured":"Soleymani M, Ebadifar A, Khosravi M, Esmaeilzadeh E, Khorram Khorshid HR. Association of rs2013162 and rs2235375 polymorphisms in IRF6 gene with susceptibility to nonsyndromic cleft lip and palate. Avicenna J Med Biotechnol. 2022;14(2):181-185. https:\/\/doi.org\/10.18502\/ajmb.v14i2.8885","journal-title":"Avicenna J Med Biotechnol"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.09.032"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23540"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1617"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1597\/12-234"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2008.0837"},{"issue":"1","key":"e_1_3_3_30_2","first-page":"201233","article-title":"MTHFR, NR3C1, FKBP5, and CRHR1 gene polymorphisms are strongly associated with depressive disorder susceptibility: A meta-analysis and power analysis","volume":"38","author":"Mohammed V","unstructured":"Mohammed V, Shanmugaraja M, Balakrishnan R. 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