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Parents\/guardians answered a questionnaire on sociodemographic, behavioral issues, and their child's medical\/dental history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Results<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>The average age of the children\/adolescents was 8.9 years (\u00b14.6). There were no confounding variables for the association between rare diseases and occlusal issues. The group with rare diseases showed a higher prevalence of occlusal alterations when compared to children\/adolescents with no rare diseases. Children\/adolescents with rare diseases showed a greater tendency to have a dolichofacial, convex facial profile, with increased lower anterior facial height and inadequate facial proportions when compared to individuals without a rare disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>Children\/adolescents with MPS and OI had a higher prevalence of malocclusion and facial alterations when compared to children\/adolescents without rare diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656251314717","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T12:42:18Z","timestamp":1756730538000},"page":"811-817","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of Orofacial Changes in Children and Adolescents With Mucopolysaccharidosis and Osteogenesis Imperfecta"],"prefix":"10.1177","volume":"63","author":[{"given":"Katherine Silvana","family":"Loayza","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6040-8935","authenticated-orcid":false,"given":"Jennifer","family":"Reis-Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-7095","authenticated-orcid":false,"given":"Nat\u00e1lia Cristina Ruy","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Lopes","family":"Angelo-Dornas","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Henrique Nogueira Guimar\u00e3es","family":"de Abreu","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina","family":"Borges-Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02343-4"},{"issue":"1","key":"e_1_3_3_3_2","article-title":"When rarity is an asset: political activism for the rights of persons with rare diseases in the Brazilian Unified National Health System","volume":"34","author":"Moreira MCN","year":"2018","unstructured":"Moreira MCN, Nascimento MAFD, Horovitz DDG, Martins AJ, Pinto M. 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