{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:40:37Z","timestamp":1777524037197,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate how craniofacial syndromes influence surgical outcomes of mandibular distraction osteogenesis (MDO), in order to optimize perioperative care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single-center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Participants<\/jats:title>\n                    <jats:p>The American College of Surgeons National Surgical Quality Improvement Program-Pediatric (NSQIP-Pediatric) database was queried for relevant Current Procedural Terminology (CPT) codes from 2012 to 2022. Patients with craniofacial syndromes were identified using ICD-9 and ICD-10 codes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Mandibular distraction osteogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>30-day perioperative adverse events including reoperation, readmission, and complications such as infection, dehiscence, pneumonia, sepsis, stroke, intracranial hemorrhage, nerve injury, and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 209 patients were identified, with 77 (36.8%) having a craniofacial syndrome. The average age at MDO was significantly younger for patients with craniofacial syndromes (99 days) versus the nonsyndromic group (389 days). Patients with craniofacial syndromes had a higher likelihood of undergoing reoperation within 30 days postoperatively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.003) and experienced a 1.5 times longer average length of stay (LOS) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.039). Additionally, these patients were less likely to achieve same-day discharge (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.033). Although the overall complication rate was slightly higher in patients with craniofacial syndromes, these differences were not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This nationwide analysis indicates that while overall complication rates for MDO are similar, those with craniofacial syndromes face greater challenges, including higher reoperation rates, longer LOS, and lower same-day discharge rates, compared to patients without craniofacial syndromes. These results underscore the need for tailored postoperative care strategies to improve outcomes for this unique patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656251325125","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T13:34:22Z","timestamp":1741095262000},"page":"1114-1122","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A Nationwide Analysis of the Impact of Craniofacial Syndromes on Mandibular Distraction Osteogenesis Outcomes"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7220-8102","authenticated-orcid":false,"given":"Raina Kushal","family":"Patel","sequence":"first","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloise W.","family":"Stanton","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Bakovic","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"The George Washington University School of Medicine and Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Mejia","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"University of Southern California, Keck School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8826-3184","authenticated-orcid":false,"given":"Asli","family":"Pekcan","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"University of Southern California, Keck School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuauhtemoc","family":"Ayala-Chavez","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"Reno School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasha","family":"Shakoori","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark M.","family":"Urata","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"University of Southern California, Keck School of Medicine"},{"name":"Keck School of Medicine"},{"name":"Herman Ostrow School of Dentistry, University of Southern California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0030-1420","authenticated-orcid":false,"given":"Jeffrey A.","family":"Hammoudeh","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"University of Southern California, Keck School of Medicine"},{"name":"Keck School of Medicine"},{"name":"Herman Ostrow School of Dentistry, University of Southern California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2020.05.016"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14508"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0133-2023"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199289010-00001"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2021.03.005"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2018.09.001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000000640"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656221076980"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29877"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001710"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/children10101591"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-0998-z"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-38-7"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2013.10.007"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656211037852"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000008611"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1046476"},{"issue":"6","key":"e_1_3_3_19_2","article-title":"Mandibular distraction osteogenesis as a primary intervention in infants with Pierre Robin sequence","volume":"86","author":"Soto E","year":"2021","unstructured":"Soto E, Ananthasekar S, Kurapati S, Robin NH, Smola C, Maddox MH, Boyd CJ, Myers RP. Mandibular distraction osteogenesis as a primary intervention in infants with Pierre Robin sequence. Ann Plast Surg. 2021;86(6S Suppl 5):S545-S549. doi:https:\/\/doi.org\/10.1097\/SAP.0000000000002702","journal-title":"Ann Plast Surg"},{"issue":"1","key":"e_1_3_3_20_2","first-page":"913807","article-title":"The long-term effects of mandibular distraction osteogenesis on developing deciduous molar teeth","volume":"2012","author":"Hong P","year":"2012","unstructured":"Hong P, Graham E, Belyea J, Taylor SM, Kearns DB, Bezuhly M. The long-term effects of mandibular distraction osteogenesis on developing deciduous molar teeth. Plast Surg Int. 2012;2012(1):913807. doi:https:\/\/doi.org\/10.1155\/2012\/913807","journal-title":"Plast Surg Int."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2011.12.023"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.04.025"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3182074799"},{"key":"e_1_3_3_24_2","volume-title":"GeneReviews\u00ae","author":"Slavotinek A","unstructured":"Slavotinek A. Fryns Syndrome. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, eds. GeneReviews\u00ae. Seattle, USA: University of Washington, April 18, 2007."},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3171\/2012.11.PEDS12297"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199812000-00008"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000009627"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656251325125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10556656251325125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656251325125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:22:31Z","timestamp":1777393351000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10556656251325125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,2]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1177\/10556656251325125"],"URL":"https:\/\/doi.org\/10.1177\/10556656251325125","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,2]]}}}