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The procedure involved symphyseal distraction and anterior mandibular alveolar osteotomy for mandibular expansion. Subsequent treatment involved LeFort I osteotomy, mandibular advancement with bilateral sagittal split osteotomy, and genioplasty, resulting in significant improvement in occlusion and facial profile. The purpose of this case report is to present the treatment outcomes of a Williams syndrome patient with severe lower arch constriction and mandibular hypoplasia, treated using an orthodontic-surgical approach.<\/jats:p>","DOI":"10.1177\/10556656251339315","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T15:23:25Z","timestamp":1747668205000},"page":"1748-1756","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Orthodontic-Surgical Approach for Treating Skeletal Class II Malocclusion with Severe Mandibular Hypoplasia in Williams Syndrome"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5767-6754","authenticated-orcid":false,"given":"Tomoya","family":"Murotani","sequence":"first","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kurosaka","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-0582","authenticated-orcid":false,"given":"Sayuri","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikawa","family":"Tomonao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamashiro","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.24.6.1311"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2008.01887.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01782"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700406"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80272-5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.161908"},{"issue":"8","key":"e_1_3_3_8_2","article-title":"Williams Syndrome with rare ureteric abnormality","volume":"13","author":"Khan J","year":"2021","unstructured":"Khan J, Al-obaidy KI, Fan R. 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