{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:59:43Z","timestamp":1781261983111,"version":"3.54.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Children with 22q11.2 deletion syndrome (22qDS) often experience velopharyngeal insufficiency. We aimed to understand outcomes following speech surgeries in children with 22qDS compared to those without.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Patients, and Outcomes<\/jats:title>\n                    <jats:p>The National Surgical Quality Improvement Program (NSQIP)-Pediatric database from 2013 to 2020 identified patients \u22653 years old who underwent speech surgery. Outcomes included postoperative length of stay (LOS) &gt;2 days and 30-day complications. Descriptive statistics and multivariable logistic regression were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 3227 patients who underwent speech surgery, 273 (8.5%) had 22qDS. They were more often premature (14.7% vs 10.1%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=.03) with worse American Society of Anesthesiologists (ASA) classification (class I: 3.3%; class II 48.3%; class III\u2009+\u200948.3% compared to those without 22qDS (24.0%, 62.7%, and 13.3%, respectively) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.0001)), with more airway abnormalities (26.7% vs 14.2%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.0001), and more cardiac risk factors (56.4% vs 8.5%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.0001). On regression analysis, 22qDS diagnosis conferred higher odds of prolonged postoperative LOS (adjusted odds ratio [aOR]: 2.02, 95% confidence interval [CI]: 1.43-2.86). Complications were associated with chronic lung disease (aOR 4.01, 95% CI: 1.46-11.06), surgeon specialty (pediatric otolaryngology vs plastics aOR0.74, 95% CI: 0.46-1.19; other specialty vs plastics aOR 0.43, 95% CI: 0.22-0.85), and ASA classification (class II vs class I aOR 1.11, 95% CI: 0.62-2.01; class III\u2009+\u2009vs class I aOR 2.30, 95% CI: 1.18-4.50); however, diagnosis of 22qDS was not associated with complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children with 22qDS undergoing speech surgery have prolonged postoperative LOS without higher odds of complications. Investigation of contributing factors including protocolization of this patient population is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656251348979","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T01:56:47Z","timestamp":1749779807000},"page":"1847-1853","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis of 22q11.2 Deletion Syndrome is not Independently Associated with Complications Following Speech Surgery: A National Surgical Quality Improvement Program Pediatric Study"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6246-7843","authenticated-orcid":false,"given":"Shruthi","family":"Srinivas","sequence":"first","affiliation":[{"name":"Nationwide Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Asti","sequence":"additional","affiliation":[{"name":"Nemours Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenna","family":"Rachwal","sequence":"additional","affiliation":[{"name":"Nemours Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine C","family":"Bergus","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Fogolin","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E","family":"Kirschner","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2766-5543","authenticated-orcid":false,"given":"Hannah","family":"Bergman","sequence":"additional","affiliation":[{"name":"Children's Mercy Hospital, Kansas City"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61601-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2005.04.009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200003000-00006"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21449"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2020.08.005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31803ecf3b"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/1055665617735102"},{"key":"e_1_3_2_9_2","article-title":"Association of Velopharyngeal Insufficiency with Quality of Life and Patient-Reported Outcomes After Speech Surgery","author":"Bhuskute A","unstructured":"Bhuskute A, Skirko JR, Roth C, Bayoumi A, Durbin-Johnson B, Tollefson TT. 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