{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:53:11Z","timestamp":1793134391615,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the impact of intraoperative packed red blood cell (pRBC) transfusion status and volume on the length of stay (LOS) for patients undergoing open or endoscopic craniosynostosis repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective consecutive case series for craniosynostosis repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>NewYork-Presbyterian\/Weill Cornell Medicine (WCM) 2016 to 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Participants<\/jats:title>\n                    <jats:p>A total of 232 patients undergoing craniosynostosis repair were included. Cases without vault remodeling or those considered non-standard\/complex were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Endoscopic or open craniosynostosis repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>LOS, complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 232 cases, 109 (47.0%) were treated with open cranial vault remodeling, and 123 (53.0%) underwent endoscopic suturectomy. Open cases had significantly higher blood loss, pRBC transfusion volume, TXA transfusion status and volume, and longer LOS (4.1\u2009\u00b1\u20094.0 days vs 1.2\u2009\u00b1\u20090.7 days). The transfusion rate was 58.7% in open cases versus 4.1% in endoscopic cases, with mean volumes of 27.9\u2009\u00b1\u200919.5\u2005cc\/kg and 17.3\u2009\u00b1\u200911.5\u2005cc\/kg, respectively. While transfusion status did not affect LOS in either cohort, multivariate linear regression, accounting for variables such as age, gender, weight, surgical approach, and case duration, found that transfusion volume independently predicted LOS. Patients with multiple sutural fusion generally had longer LOS than patients with singular sutural fusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Minimizing transfusion volumes could reduce LOS, emphasizing the need for improved surgical planning and anesthetic strategies to reduce transfusion burden. This study's retrospective, single-center design limits its generalizability, necessitating prospective trials to standardize transfusion criteria and assess the impact of preoperative hemoglobin and hematocrit's role in outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656251352733","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T02:01:33Z","timestamp":1751335293000},"page":"1920-1928","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Intraoperative Transfusion Volume on Length of Stay in Synostosis Repair"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9545-8502","authenticated-orcid":false,"given":"Alexandra","family":"Giantini Larsen","sequence":"first","affiliation":[{"name":"NewYork-Presbyterian Hospital\/Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Pandey","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital\/Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Kharas","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital\/Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Buontempo","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital\/Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Adelhoefer","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital\/Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makayla","family":"Kochheiser","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital\/Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0073-953X","authenticated-orcid":false,"given":"Alyssa B","family":"Valenti","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital\/Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Imahiyerobo","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital\/Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin E","family":"Hoffman","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital\/Weill Cornell Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/2011.3.PEDS10418"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-020-04654-y"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/2014.4.PEDS13449"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2017.01.029"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004098"},{"issue":"2","key":"e_1_3_2_7_2","article-title":"Calculated blood loss and transfusion requirements in primary open repair of craniosynostosis","volume":"7","author":"Lopez MM","year":"2019","unstructured":"Lopez MMJr., Lee J, Morrison K, Hoffman C, Souweidane M, Ascherman JA. 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