{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:14:34Z","timestamp":1783426474028,"version":"3.54.6"},"reference-count":26,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Intraoperative transfusion during corrective surgery for craniosynostosis is common. We sought to evaluate determinants of intraoperative transfusion for patients with nonsyndromic, single-suture craniosynostosis undergoing primary repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>We queried the multicenter Pediatric Craniofacial Surgery Perioperative Registry for patients undergoing correction of craniosynostosis between June 2012 and January 2023. Nonsyndromic patients who underwent primary repair of single suture craniosynostosis at &lt;12 months of age were included. Univariate and multivariate logistic regressions were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure<\/jats:title>\n                    <jats:p>Intraoperative transfusion requirement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 3994 patients met inclusion criteria, and 2261 (56.6%) received an intraoperative blood transfusion. Those who received an intraoperative transfusion had longer surgery duration (93.8\u2009\u00b1\u20091.5 vs 180.1\u2009\u00b1\u20091.9\u2005min,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), increased weight (6.8\u2009\u00b1\u20090.04 vs 7.8\u2009\u00b1\u20090.03\u2005kg,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and were older (4.1\u2009\u00b1\u20090.1 vs 6.6\u2009\u00b1\u20090.1 months,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and more likely female (odds ratio [OR] 1.18, 95% confidence interval [CI]:1.03-1.35,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.018). For 144 (3.6%) patients who received preoperative iron supplementation, the incidence of intraoperative transfusion was decreased (OR 0.39; 95%CI: 0.27-0.57,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). In multivariate analysis, factors independently associated with higher odds of intraoperative transfusion included longer surgery duration (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), increasing age (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.017), lower weight (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.011), higher American Society of Anesthesiologists class (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), procedure (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) (especially nonendoscopic), lack of preoperative iron supplementation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and lower preoperative hemoglobin (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.038).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Various factors influence the incidence of transfusion in patients undergoing primary surgical correction of single suture craniosynostosis. Timing of surgery and optimization of preoperative hemoglobin with iron supplementation represent possible modifiable risk factors that warrant additional, prospective study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656251379006","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T04:45:54Z","timestamp":1758602754000},"page":"2413-2420","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictors of Transfusion Outcomes for Patients Undergoing Surgical Correction of Craniosynostosis: A Multicenter Retrospective Analysis"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2780-7894","authenticated-orcid":false,"given":"Gwendolyn E.","family":"Daly","sequence":"first","affiliation":[{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew K.","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha E.","family":"Wong","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Gries","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Stricker","sequence":"additional","affiliation":[{"name":"Children's Hospital of Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6712-0224","authenticated-orcid":false,"given":"Spencer T.","family":"Hills","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori K.","family":"Howell","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan R.","family":"Selden","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik M.","family":"Wolfswinkel","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Pediatric Craniofacial Collaborative 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