{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:11:02Z","timestamp":1788667862460,"version":"build-2803163510"},"reference-count":28,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess volumetric and morphological changes in the maxillary sinus of patients with cleft lip and palate (CLP) undergoing Le Fort I osteotomy using cone-beam computed tomography (CBCT) and 3D segmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective observational pilot study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A specialized CLP treatment center in the oral and maxillofacial surgery department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Participants<\/jats:title>\n                    <jats:p>Thirty adults with CLP (15 unilateral, 15 bilateral) who underwent Le Fort I osteotomy, with preoperative and \u226512-month postoperative CBCT scans available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three-dimensional segmentation of the maxillary sinus was performed using ITK-SNAP software on pre- and postoperative CBCT scans to calculate volumetric changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome Measure<\/jats:title>\n                    <jats:p>\n                      Maxillary sinus volume (mm\n                      <jats:sup>3<\/jats:sup>\n                      ) before and after surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both groups exhibited postoperative reductions in sinus volume. In the unilateral group, mean bilateral volume decreased from 12\u2005272\u2005mm\n                      <jats:sup>3<\/jats:sup>\n                      to 11\u2005433\u2005mm\n                      <jats:sup>3<\/jats:sup>\n                      ; in the bilateral group, from 15\u2005082\u2005mm\n                      <jats:sup>3<\/jats:sup>\n                      to 14\u2005519\u2005mm\n                      <jats:sup>3<\/jats:sup>\n                      . Although the unilateral group showed slightly greater reduction, differences were not statistically significant within or between groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Le Fort I osteotomy led to modest postoperative volumetric reduction in the maxillary sinus in both unilateral and bilateral CLP patients. Bilateral CLP cases consistently exhibited larger sinus volumes pre- and postoperatively compared to unilateral cases. These findings suggest cleft morphology influences sinus anatomy and that surgical intervention may alter its structure. Although volumetric changes were not significant, frequent morphological variations highlight the need for ongoing postoperative radiological monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656251385463","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T17:03:12Z","timestamp":1761757392000},"page":"3225-3231","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Volumetric Assessment of Maxillary Sinus Changes After Le Fort I Osteotomy in Cleft Lip and Palate Patients: A Pilot Study"],"prefix":"10.1177","volume":"63","author":[{"given":"Peterson Rogerio","family":"Garcia","sequence":"first","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0369-2757","authenticated-orcid":false,"given":"Caroline de Paula Oliveira","family":"Gringo","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0825-4972","authenticated-orcid":false,"given":"Gustavo Ribeiro","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Bauru School of Dentistry, University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle Ferreira de","family":"Souza","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Stacy Gallegos","family":"Soto","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo"},{"name":"Bauru School of Dentistry, University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2576-7887","authenticated-orcid":false,"given":"Renato Yassutaka","family":"Faria Yaedu","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2022.10.051"},{"issue":"6","key":"e_1_3_2_3_2","first-page":"523","article-title":"Relapse-related factors of Le Fort I osteotomy in cleft lip and palate patients: A systematic review and meta-analysis.","volume":"49","author":"Lee S","year":"2021","unstructured":"Lee S, Park JY, Kim Y, Wolvius EB, Phillips DE, Kuster M, Zanchetta M, Park JY, Li KK, Precious DS, et al. Relapse-related factors of Le Fort I osteotomy in cleft lip and palate patients: A systematic review and meta-analysis. J Cranio-Maxillofacial Surg. 2021;49(6):523\u2013530. doi:10.1016\/j.jcms.2021.03.001. Epub 2021 Mar 11. PMID: 3371892.","journal-title":"J Cranio-Maxillofacial Surg"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-5406(05)81729-9"},{"issue":"4","key":"e_1_3_2_5_2","first-page":"456","article-title":"Differences in the surgical and financial burden of four protocols for unilateral cleft lip and palate","volume":"54","author":"Kawakami M","year":"2025","unstructured":"Kawakami M, Lee S, Smahel Z, Kim Y, Park JY, Wolvius EB, Phillips DE, Kuster M, Zanchetta M, Park JY, et al. Differences in the surgical and financial burden of four protocols for unilateral cleft lip and palate. Int J Oral Maxillofac Surg. 2025; 54(4):456\u2013463.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2017.01.027"},{"issue":"1","key":"e_1_3_2_7_2","first-page":"45","article-title":"Peri- and postoperative complications in Le Fort I osteotomies","volume":"120","author":"Park JY","year":"2021","unstructured":"Park JY, Wolvius EB, Phillips DE, Kuster M, Zanchetta M, Park JY, Li KK, Precious DS, Moffat DA, Shrout PE, et al. Peri- and postoperative complications in Le Fort I osteotomies. J Formos Med Assoc. 2021;120(1):45\u201352.","journal-title":"J Formos Med Assoc."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(86)90189-8"},{"issue":"9","key":"e_1_3_2_9_2","first-page":"789","article-title":"Is post orthognathic maxillary sinusitis related to sino-nasal anatomical alterations?","volume":"117","author":"Phillips DE","year":"2018","unstructured":"Phillips DE, Kuster M, Zanchetta M, Park JY, Li KK, Precious DS, Moffat DA, Shrout PE, Aizenbud D, Landes CA, et al. Is post orthognathic maxillary sinusitis related to sino-nasal anatomical alterations?. J Formos Med Assoc. 2018;117(9):789\u2013795.","journal-title":"J Formos Med Assoc"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40902-019-0195-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000006659"},{"issue":"4","key":"e_1_3_2_12_2","first-page":"119","article-title":"Radiographic assessment of findings in the maxillary sinus using cone-beam computed tomography","volume":"15","author":"Dobele I","year":"2013","unstructured":"Dobele I, Kise L, Apse P, Kragis G, Bigestans A. Radiographic assessment of findings in the maxillary sinus using cone-beam computed tomography. Stomatologija. 2013;15(4):119\u2013122. PMID: 24589634.","journal-title":"Stomatologija"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1735309"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.9654"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2021.10.006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.10.006"},{"key":"e_1_3_2_17_2","volume-title":"Surgical Correction of Dentofacial Deformities","author":"Bell WH","year":"1980","unstructured":"Bell WH, Proffit WR, White RP, Sarver DM, Fonseca RJ, Turvey TA, Miloro M, Pogrel MA, Bailey LJ, Shaughnessy TA, et al. Surgical Correction of Dentofacial Deformities, Vol. 1. Philadelphia: WB Saunders; 1980."},{"issue":"7","key":"e_1_3_2_18_2","first-page":"1130","article-title":"Maxillary sinus volume changes after orthognathic surgery in cleft patients","volume":"45","author":"Zanchetta LM","year":"2017","unstructured":"Zanchetta LM, Park YW, Bornstein MM, Landes CA, Aboul-Hosn Centenero S, Bell WH, Proffit WR, White RP, Sarver DM, Fonseca RJ, et al. Maxillary sinus volume changes after orthognathic surgery in cleft patients. J Craniomaxillofac Surg. 2017;45(7):1130\u20131136.","journal-title":"J Craniomaxillofac Surg"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2022.10.009"},{"issue":"3","key":"e_1_3_2_20_2","first-page":"213","article-title":"The changes in upper airway volume after orthognathic surgery evaluated by individual segmentation on CBCT images","volume":"14","author":"Faur CI","year":"2019","unstructured":"Faur CI, Roman RA, Bran S, Dinu C, Coclici A, Rotaru H, Hedesiu M. The changes in upper airway volume after orthognathic surgery evaluated by individual segmentation on CBCT images. Maedica (Bucur). 2019;14(3):213\u2013219. PMID: 31798735; PMCID: PMC6861713.","journal-title":"Maedica (Bucur)"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.2.420"},{"key":"e_1_3_2_22_2","first-page":"182","article-title":"Long-term outcomes of LeFort I maxillary advancement in cleft lip and palate patients: Sinus health and dental stability","volume":"83","author":"Aizenbud D","year":"2016","unstructured":"Aizenbud D, Shrout PE, Bell WH, Proffit WR, White RP, Sarver DM, Fonseca RJ, Turvey TA, Miloro M, Pogrel MA, et al. Long-term outcomes of LeFort I maxillary advancement in cleft lip and palate patients: Sinus health and dental stability. Int J Pediatr Otorhinolaryngol. 2016;83:182\u2013188.","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000006659"},{"issue":"6","key":"e_1_3_2_24_2","first-page":"412","article-title":"Le Fort I osteotomy for correction of maxillary deformities","volume":"33","author":"Bell WH","year":"1975","unstructured":"Bell WH. Le Fort I osteotomy for correction of maxillary deformities. J Oral Surg (Chic). 1975;33(6):412\u2013426.","journal-title":"J Oral Surg (Chic)."},{"key":"e_1_3_2_25_2","first-page":"31","volume-title":"Oral Surg Oral Med Oral Pathol Oral Radiol","author":"Heli\u00f6vaara S","year":"2020","unstructured":"Heli\u00f6vaara S, et al. Association between orthognathic surgery and sinonasal symptoms: a 5-year follow-up. Oral Surg Oral Med Oral Pathol Oral Radiol. 2020;129(1):31\u201339."},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","unstructured":"Imbrogno G Lorenzi A Borloni R Scaini R Testori T Felisati G Saibene AM Craig JR. Maxillary sinusitis following orthognathic surgery: Should it be considered odontogenic sinusitis? Clin Case Rep. 2024;12(12):e9654. PMID: 39619300; PMCID: PMC11606932.","DOI":"10.1002\/ccr3.9654"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-023-01598-y"},{"issue":"5","key":"e_1_3_2_28_2","first-page":"858","article-title":"Comparison of conventional and semi-automated 3D volumetric assessment of maxillary sinuses after Le Fort I osteotomy","volume":"71","author":"Landes CA","year":"2013","unstructured":"Landes CA, Aboul-Hosn Centenero S, Zanchetta LM, Park,YW, Bornstein MM, Bell WH, Proffit WR, White RP, Sarver DM, Fonseca RJ, et al. Comparison of conventional and semi-automated 3D volumetric assessment of maxillary sinuses after Le Fort I osteotomy. J Oral Maxillofac Surg. 2013;71(5):858\u2013864.","journal-title":"J Oral Maxillofac Surg"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190770"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656251385463","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10556656251385463","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656251385463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T03:39:25Z","timestamp":1788665965000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10556656251385463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/10556656251385463"],"URL":"https:\/\/doi.org\/10.1177\/10556656251385463","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]}}}