{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:57:20Z","timestamp":1790776640274,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of the study was to compare the prevalence of Chronic Abdominal Pain (CAP) and Functional Constipation (FC) in children and adolescents with and without Cleft Lip and\/or Palate (CL\/P).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cross-sectional.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Craniofacial Center, Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The present study included 400 participants, aged from 4 to 18 years, divided into 2 groups: non-syndromic CL\/P (n\u2009=\u2009200) and without CL\/P (n\u2009=\u2009200; control group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>The parents of the participants answered the questions and were interviewed based on the criteria of Apley and Naish for CAP's diagnosis and on ROME IV criteria for FC diagnosis. The obtained prevalence in the groups were compared using chi-square test (\u03b1=5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>The hypothesis is that individuals with oral cleft might have a higher prevalence of those chronic conditions, based on the frequent early life stressors in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CAP prevalence was 36.50% in CL\/P group and 15.00% in control (without CL\/P) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). The FC prevalence in CL\/P group was 24.50% and 18.50% in control group (without CL\/P) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.180).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Children and adolescents with CL\/P had a higher CAP prevalence compared to the population without CL\/P. FC percentage were expressive in both groups. Gastrointestinal problems may represent additional suffering for the patients with clefts. The proper management of chronic conditions of the gastrointestinal tract in children and adolescents with CL\/P should be part of the patient's rehabilitation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656251386561","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:10:49Z","timestamp":1761156649000},"page":"2744-2748","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Chronic Gastrointestinal Disorders in Patients With Cleft Lip and\/or Palate"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-6198","authenticated-orcid":false,"given":"Eliane Alves Motta","family":"Cabello Santos","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-3832","authenticated-orcid":false,"given":"Elo\u00e1 Cristina Passucci","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3460-3144","authenticated-orcid":false,"given":"Thais Marchini","family":"Oliveira","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-77572012000100003"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-0628"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2018.vol32.0024"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.1925"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1597\/09-046"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0323"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1597\/05-172"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01847.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2011.01244.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmx.2013.02.001"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.04.036"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-310694"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i30.6864"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0873-0"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126982"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.02.029"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181de0639"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0114"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0222-y"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/picr.picr_100_24"},{"key":"e_1_3_3_22_2","first-page":"289","article-title":"Sample size estimation in epidemiologic studies","volume":"2","author":"Hajian-Tilaki K","year":"2011","unstructured":"Hajian-Tilaki K. 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