{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:48:27Z","timestamp":1793382507609,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Brazilian Federal Agency CAPES","award":["Finance Code 001, process No. 88881.800634\/2022-01"],"award-info":[{"award-number":["Finance Code 001, process No. 88881.800634\/2022-01"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The mandibular symphysis is a donor site for alveolar bone grafting (ABG) in patients with cleft lip and\/or palate, offering reduced morbidity. This prospective study evaluated ABG outcomes and donor site regeneration using artificial intelligence (AI)-powered 3-dimensional (3D) tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary-level craniofacial hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients, Participants<\/jats:title>\n                    <jats:p>Twenty-one patients with cleft lip and alveolus (mean age 12.1\u2009\u00b1\u20093.2 years), and without syndromes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Alveolar bone grafting was performed using mandibular symphysis bone by an experienced surgeon at a single center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Pre- and one-year postoperative cone-beam computed tomography scans were analyzed using AI-powered 3D tools to assess alveolar bone defect and bone bridge formation in terms of thickness, mediolateral extension, and height. Donor site regeneration was evaluated by shape correspondence analysis comparing pre- and postharvesting morphology. Pulp vitality, mental nerve sensory disturbances, and length of hospital stay were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At one-year follow-up, cleft defects were reduced to near-zero in all dimensions. The bone bridge reached mean values of 11.6\u2009\u00b1\u20093.4\u2005mm buccopalatally, 20.7\u2009\u00b1\u20092.7\u2005mm mediolaterally, and 14.6\u2009\u00b1\u20094.2\u2005mm vertically. Donor site regeneration was highly favorable, requiring 2.73\u2009\u00b1\u20091.3\u2005mm of residual bone formation. All patients were discharged within 24\u2005h, with minimal discomfort and no complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings confirm mandibular symphysis bone as a reliable graft source and support the clinical value of AI-powered 3D approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656251393077","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T17:36:08Z","timestamp":1762796168000},"page":"2791-2798","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Mandibular Symphysis Bone for Alveolar Grafting: 3D Outcomes and Donor Site Regeneration in Patients With Unilateral Cleft Lip and Alveolus"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-8170","authenticated-orcid":false,"given":"Bruno Mariano Ribeiro","family":"Braga","sequence":"first","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6430-612X","authenticated-orcid":false,"given":"Claudia","family":"Resende Leal","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-2580","authenticated-orcid":false,"given":"Roberta Martinelli","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-6714","authenticated-orcid":false,"given":"Mar\u00edlia Sayako","family":"Yatabe-Ioshida","sequence":"additional","affiliation":[{"name":"University of Michigan School of Dentistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-416X","authenticated-orcid":false,"given":"Cristiano","family":"Tonello","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1743-4484","authenticated-orcid":false,"given":"Rodrigo","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Bauru School of Dentistry, University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9786-2253","authenticated-orcid":false,"given":"Lucia Helena Soares","family":"Cevidanes","sequence":"additional","affiliation":[{"name":"University of Michigan School of Dentistry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terumi Okada","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60695-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000337464"},{"issue":"2","key":"e_1_3_3_4_2","first-page":"127","article-title":"Secondary bone grafting of alveolar clefts","volume":"15","author":"Abyholm FE","year":"1981","unstructured":"Abyholm FE, Bergland O, Semb G. Secondary bone grafting of alveolar clefts. Scand J Plast Reconstr Surg. 1981;15(2):127-140.","journal-title":"Scand J Plast Reconstr Surg"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-77572012000100003"},{"issue":"2","key":"e_1_3_3_6_2","first-page":"87","article-title":"Secondary bone grafting of residual alveolar and palatal clefts","volume":"30","author":"Boyne PJ","year":"1972","unstructured":"Boyne PJ, Sands NR. Secondary bone grafting of residual alveolar and palatal clefts. J Oral Surg. 1972;30(2):87-92.","journal-title":"J Oral Surg"},{"issue":"3","key":"e_1_3_3_7_2","first-page":"175","article-title":"Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orthodontic treatment","volume":"23","author":"Bergland O","year":"1986","unstructured":"Bergland O, Semb G, Abyholm FE. Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orthodontic treatment. Cleft Palate J. 1986;23(3):175-205.","journal-title":"Cleft Palate J"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_1991_028_0301_cotspf_2.3.co_2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(10)80466-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2001_038_0155_mbgmfr_2.0.co_2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1597\/03-158.1"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1597\/09-172"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2013.09.007"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1597\/14-143"},{"key":"e_1_3_3_15_2","unstructured":"Bastos-J\u00fanior JC. Resultado de enxertos \u00f3sseos alveolares com osso aut\u00f3geno de s\u00ednfise em fissuras completas de l\u00e1bio e palato unilaterais. [Thesis]. Bauru: Hospital de Reabilita\u00e7\u00e3o de Anomalias Craniofaciais Universidade de S\u00e3o Paulo; 2019."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.03.012"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1055665618780981"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1055665617738401"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.11606\/T.61.2011.tde-14022012-100227"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-5182(05)80411-1"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.11607\/jop.1062"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1597\/15-193"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.123"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20180047"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2002_039_0255_anstar_2.0.co_2"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/25.2.205"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1051\/orthodfr\/2009021"},{"issue":"5","key":"e_1_3_3_28_2","first-page":"1012","article-title":"Deep learning-based three-dimensional analysis reveals distinct patterns of condylar remodelling after orthognathic surgery in skeletal class III patients","volume":"14","author":"Barone S","year":"2025","unstructured":"Barone S, Cevidanes L, Bianchi J, , Goncalves JR, , Giudice A. Deep learning-based three-dimensional analysis reveals distinct patterns of condylar remodelling after orthognathic surgery in skeletal class III patients. J Clin Med. 2025;14(5):1012.","journal-title":"J Clin Med"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2017.01.029"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2020.01.003"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e3182519ab5"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2022.48.2.85"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656241271672"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.12.010"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2022-0478"},{"key":"e_1_3_3_36_2","first-page":"165","article-title":"Autogenous bone harvesting: a chin graft technique for particulate and monocortical bone blocks","volume":"19","author":"Hunt DR","year":"1999","unstructured":"Hunt DR, Jovanovic SA. Autogenous bone harvesting: a chin graft technique for particulate and monocortical bone blocks. Int J Periodontics Restorative Dent. 1999;19:165.","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.06.001"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2017.07.143"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656251393077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10556656251393077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656251393077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:11:49Z","timestamp":1790773909000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10556656251393077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/10556656251393077"],"URL":"https:\/\/doi.org\/10.1177\/10556656251393077","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}