{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:57:20Z","timestamp":1790776640320,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"\n Objective<\/jats:title>\n The present study was conducted with the objective of comparing the efficacy of microneedling with vitamin C serum versus platelet-rich plasma (PRP) in the management of the appearance of post-operative cleft lip scars.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n The study was conducted as a prospective, randomized comparative study.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n A total of 30 participants (\n n<\/jats:italic>\n \u2009=\u200930) were included in the study, with each group comprising of 15 participants.\n <\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Smile train verified cleft center.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n Each patient underwent three sessions of microneedling combined with the assigned adjuvant, PRP in group A and vitamin C serum in group B. Follow-up evaluations were conducted at 1, 2, and 3 months post-operatively.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures<\/jats:title>\n \n The scar quality and improvements were assessed using the patient and observer scar assessment scale (POSAS), graded from 1 to 10 by each patient and a fixed outer observer from the department of oral and maxillofacial surgery.\n p<\/jats:italic>\n \u2009\u2264\u20090.5 was considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Results indicated that while both modalities offer significant improvements in scar appearance, texture, and overall esthetic outcomes, PRP showed superior results in terms of scar reduction and patient-reported satisfaction (\n p<\/jats:italic>\n \u2009<\u20090.05). However, pliability (\n p<\/jats:italic>\n \u2009=\u20090.10) and pain (\n p<\/jats:italic>\n \u2009=\u20090.28) scores did not show a statistically significant difference between the two groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Through this study, we concluded that microneedling when combined with PRP offers far more superior results in terms of improvement of the scar appearance as compared to vitamin C serum.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10556656251395554","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:04:51Z","timestamp":1763748291000},"page":"2849-2859","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analysis of Microneedling With PRP Versus Vitamin C Serum in the Management of Post-Operative Cleft lip Scars"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6352-4587","authenticated-orcid":false,"given":"Sameera","family":"Dawar","sequence":"first","affiliation":[{"name":"SGT University, FDS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Gupta","sequence":"additional","affiliation":[{"name":"SGT University, FDS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9597-8586","authenticated-orcid":false,"given":"Varun","family":"Arya","sequence":"additional","affiliation":[{"name":"SGT University, FDS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Kumar","sequence":"additional","affiliation":[{"name":"SGT University, FDS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"issue":"1","key":"e_1_3_2_2_2","article-title":"Genetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts","volume":"13","author":"Stanier P","year":"2004","unstructured":"Stanier P, Moore GE. Genetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts. Hum Mol Genet. 2004;13(Suppl. 1):R73-R81.","journal-title":"Hum Mol Genet"},{"key":"e_1_3_2_3_2","unstructured":"Fonseca JR. Cleft\/craniofacial\/cosmetic surgery. Vol. 6. Saunders BW; year unknown:3."},{"key":"e_1_3_2_4_2","first-page":"57","volume-title":"Biological basis of facial plastic surgery","author":"Sykes JM","year":"1993","unstructured":"Sykes JM, Senders CW. Pathologic anatomy of cleft lip, palate and nasal deformity. In: Meyers AD, ed. Biological basis of facial plastic surgery. Syria: Thieme; 1993:57-71."},{"issue":"4","key":"e_1_3_2_5_2","first-page":"187","article-title":"Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups","volume":"4","author":"Soltani AM","year":"2012","unstructured":"Soltani AM, Francis CS, Motamed A, Karatsonyi AL, Hammoudeh JA, Sanchez-Lara PA, Reinisch JF, Urata MM. 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Risk factors and comorbidities in Brazilian patients with orofacial clefts. Braz Oral Res. 2018;32(7):e68.","journal-title":"Braz Oral Res"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.150742"},{"issue":"4","key":"e_1_3_2_13_2","first-page":"205951311988030","article-title":"Percutaneous collagen induction (microneedling) for the management of non-atrophic scars: literature review","volume":"5","author":"Iosifidis C","year":"2019","unstructured":"Iosifidis C, Goutos I. Percutaneous collagen induction (microneedling) for the management of non-atrophic scars: literature review. Scars Burn Heal. 2019;5(4):2059513119880304.","journal-title":"Scars Burn Heal"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2017.02.006"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjaa392"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01999.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.788754"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0690-3"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2019.1668016"},{"key":"e_1_3_2_21_2","unstructured":"Tuknayat A Menon D Bansal A Garg S. The role of platelet-rich plasma (PRP). The elixir of platelet rich plasma therapy in intervention dermatology and regenerative trichology. 2023;146:146-150."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15239"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2012.11.009"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13714"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164741"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2019.01571"},{"issue":"2","key":"e_1_3_2_27_2","first-page":"6","article-title":"Evaluation of the effect of platelet-rich plasma on post-burn scars","volume":"5","author":"Elsayed M","year":"2017","unstructured":"Elsayed M, Moaty MA, Moghazy A, Eldeen OS. Evaluation of the effect of platelet-rich plasma on post-burn scars. 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