{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:11:05Z","timestamp":1788667865088,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the neuroendocrine axis in patients with arhinia, hemiarhinia, and their associated malformations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were manually extracted from medical records at Hospital de Reabilita\u00e7\u00e3o de Anomalias Craniofaciais, Universidade de S\u00e3o Paulo (HRAC-USP) using a newly developed protocol. They were explored through a descriptive and qualitative manner. This study was approved by the HRAC-USP Ethics Committee and is part of a large research project on this topic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine patients were included in the final sample, of which three had isolated hemiarhinia, three had hemiarhinia with additional malformations, and three were diagnosed with Bosma arhinia-microphthalmia (BAM) syndrome. Among those with isolated hemiarhinia, two presented neuroendocrine alterations (primary hypothyroidism, micropenis with bilateral cryptorchidism, and weight and height deficits). Patients with hemiarhinia and associated malformations demonstrated no clinical or laboratory evidence of neuroendocrine dysfunction. In the BAM syndrome group, two patients exhibited central hypogonadotropic dysfunction, with undetectable luteinizing hormone and follicle-stimulating hormone levels. The third patient showed no abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Arhinia, hemiarhinia, and their associated malformations encompass a broad spectrum of manifestations that can affect multiple organs and systems, particularly the neuroendocrine system. Despite their potential impact, screening for these conditions remains poorly conducted, which may lead to underdiagnosis or delayed recognition of associated complications. Consequently, a comprehensive evaluation is essential to ensure appropriate monitoring and management of affected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656251406418","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:52:54Z","timestamp":1766749974000},"page":"3463-3469","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroendocrine Axis Investigation in Patients with Arhinia, Hemiarhinia and Associated Malformations"],"prefix":"10.1177","volume":"63","author":[{"given":"Luisa Helena Assis","family":"Bustamante","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo (HRAC-USP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Casarin Henrique","family":"Sanches","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (HRAC-USP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3205-7249","authenticated-orcid":false,"given":"Lucas Casagrande Passoni","family":"Lopes","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (FMRBU-USP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Contrucci Dantas","family":"Segarra","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (HRAC-USP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siulan Vendramini Paulovich","family":"Pittoli","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (HRAC-USP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosei Maria Zechi","family":"Ceide","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (HRAC-USP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Mizue Kokitsu","family":"Nakata","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (HRAC-USP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Tonello","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (HRAC-USP)"},{"name":"Universidade de S\u00e3o Paulo (FMRBU-USP)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Antonio","family":"Negrato","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (HRAC-USP)"},{"name":"Universidade de S\u00e3o Paulo (FMRBU-USP)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.110083"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2016-0082"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa065"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9957218"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-016-1009-x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000005091"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.12.013"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215121000219"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.63640"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179425"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005958"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67715-x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3765"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0000000000000101"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.5604\/00306657.1199344"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304412"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/01676830.2017.1280059"},{"issue":"7","key":"e_1_3_2_19_2","first-page":"99","article-title":"Primary empty sella syndrome and the prevalence of hormonal dysregulation","volume":"115","author":"Auer MK","year":"2018","unstructured":"Auer MK, Stieg MR, Crispin A, Sievers C, Stalla GK, Kopczak A. 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