{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:11:12Z","timestamp":1788667872246,"version":"build-2803163510"},"reference-count":33,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"JSPS KAKENHI Grant","award":["This work was supported by JSPS KAKENHI (the Minis"],"award-info":[{"award-number":["This work was supported by JSPS KAKENHI (the Minis"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>No studies have examined the effectiveness of platelet-rich plasma (PRP) alone and platelet-rich fibrin (PRF) without alveolar bone grafting or other bone substitutes for alveolar cleft repair during infancy. This study evaluated the effectiveness of autologous PRP\/PRF on alveolar regeneration in infantile unilateral cleft lip and alveolus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Patients, Participants: A total of 56 patients with alveolar clefts were classified into the no PRP\/PRF (which received gingivoperiosteoplasty [GPP] without PRP\/PRF), PRP (which received GPP with PRP), and PRF (which received GPP with PRF) groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Regarding preparation, 5\u2005mL of blood was withdrawn, and 1\u2005mL each of PRP and PRF was prepared via centrifugal separation. PRP was implanted in the alveolar cleft after loading it into a commercially available gelatin sponge, while PRF was implanted directly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Postoperative bone formation was assessed using computed tomography and radiography for qualitative analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The new alveolar bone volume was higher in the PRF group than in the other groups; however, no differences were observed between the PRP, PRF, and control groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study was performed without complication. However, no significant difference in bone formation was found between the PRP, PRF, and control groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261417033","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:18:10Z","timestamp":1781860690000},"page":"3445-3453","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Implantation of Infant Platelet-Rich Plasma\/Fibrin with Gingivoperiosteoplasty in Patients with Unilateral Cleft Lip and Alveolus"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2058-5678","authenticated-orcid":false,"given":"Shinji","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Kanagawa Children's Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Yabuki","sequence":"additional","affiliation":[{"name":"Kanagawa Children's Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0277-6358","authenticated-orcid":false,"given":"Madoka","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Kanagawa Children's Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atuko","family":"Fukui","sequence":"additional","affiliation":[{"name":"Kanagawa Children's Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Kanagawa Children's Medical Center"},{"name":"Hirakawa Orthodontic Clinic, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"issue":"3","key":"e_1_3_2_2_2","first-page":"175","article-title":"Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orthodontic treatment","volume":"23","author":"Bergland O","year":"1986","unstructured":"Bergland O, Semb G, Abyholm FE. Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orthodontic treatment. Cleft Palate J. 1986;23(3):175\u2010205.","journal-title":"Cleft Palate J"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1597\/15-193"},{"key":"e_1_3_2_4_2","first-page":"332","article-title":"The use of periosteal flaps in the repair of clefts of the primary palate","volume":"2","author":"Skoog T","year":"1965","unstructured":"Skoog T. The use of periosteal flaps in the repair of clefts of the primary palate. 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