{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:01:17Z","timestamp":1791489677781,"version":"4.3.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The present meta-analysis has been conducted with the objective of conducting a precise examination of the association between 6\n                      <jats:italic toggle=\"yes\">IRF6<\/jats:italic>\n                      gene polymorphisms and the risk of nonsyndromic cleft lip with or without palate (CL\u2009\u00b1\u2009P) among various ethnic groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The meta-analysis incorporated a total of 53 published case-control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were computed. A leave-1-out sensitivity analysis was conducted, in conjunction with an investigation into publication bias, under the dominant model. Subgroup analysis based on ethnicity was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The rs642961 was associated with an increased risk (AA\u2009+\u2009AG vs GG; OR: 1.31; 95% CI: 1.10-1.55;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.02;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200970%), while rs2235371 significantly reduced risk (AA\u2009+\u2009AG vs GG; OR: 0.74; 95% CI: 0.60-0.92;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.007;\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200975%) of CL\u2009\u00b1\u2009P. The remaining single-nucleotide polymorphisms (rs861019, rs2013162, rs2235373, and rs2235375) were not associated with the risk of CL\u2009\u00b1\u2009P. Subgroup analysis based on ethnicity revealed distinct ethnicity-specific effects, with rs861019 associated with increased CL\u2009\u00b1\u2009P risk in Caucasians, rs642961 increasing risk in Asians and mixed populations, and rs2235371 reducing risk only in Caucasians.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      While\n                      <jats:italic toggle=\"yes\">IRF6<\/jats:italic>\n                      gene rs642961 and rs2235371 were found to be associated with an increased risk of CL\u2009\u00b1\u2009P in all studies, there was suggestive evidence of ethnic-specific differences, particularly among Caucasian and Asian populations. Although this study lends further support to the notion of an association between CL\u2009\u00b1\u2009P and the\n                      <jats:italic toggle=\"yes\">IRF6<\/jats:italic>\n                      gene polymorphisms, it is clear that further studies including diverse cohorts are needed to provide fully validated, ethnic- or population-specific insights.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261420470","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T18:14:13Z","timestamp":1770660853000},"page":"3620-3627","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["IRF6 Gene Polymorphisms Influence the Susceptibility of Nonsyndromic Cleft Lips With or Without Palate: A MOOSE-Compliant Meta-Analysis"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3213-0445","authenticated-orcid":false,"given":"Rubin","family":"Sahu","sequence":"first","affiliation":[{"name":"Guru Ghasidas Vishwavidyalaya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6765-3642","authenticated-orcid":false,"given":"Subhra Malinee","family":"Mishra","sequence":"additional","affiliation":[{"name":"Guru Ghasidas Vishwavidyalaya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-7618","authenticated-orcid":false,"given":"Prasad","family":"Nalabothu","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery, University Hospital Basel, Basel, Switzerland"},{"name":"Department of Pediatric Oral Health and Orthodontics, University Center for Dental Medicine Basel UZB, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3562-8263","authenticated-orcid":false,"given":"Syed Altaf","family":"Hussain","sequence":"additional","affiliation":[{"name":"Sree Balaji Medical College and Rela Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2977-6454","authenticated-orcid":false,"given":"LVKS","family":"Bhaskar","sequence":"additional","affiliation":[{"name":"Guru Ghasidas Vishwavidyalaya"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2019.12.002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4274\/jtgga.galenos.2022.2021-10-7"},{"key":"e_1_3_2_4_2","first-page":"1","volume-title":"Surgical atlas of cleft palate and palatal fistulae","author":"Ye X","year":"2020","unstructured":"Ye X, Ahmed MK. 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