{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:56:27Z","timestamp":1791489387433,"version":"4.3.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this systematic review and meta-analysis was to compare the outcomes of secondary alveolar bone grafting (SABG) performed before and after 12 years of age in patients with nonsyndromic cleft alveolus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>All relevant studies from database untill September 2024 were identified through all relevant databases. Randomized Controlled Trials (RCTs), Controlled Clinical Trials (CCTs), prospective, and retrospective studies were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Population<\/jats:title>\n                    <jats:p>Patients with cleft alveolus who underwent SABG using iliac crest bone graft.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Early SABG performed below 12 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Comparison<\/jats:title>\n                    <jats:p>SABG performed on or after 12 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary outcome<\/jats:title>\n                    <jats:p>Bone fill assessed through radiographic imaging techniques. Secondary outcomes included skeletal relationship, canine eruption, Asher-Mcdade index, Goslon yardstick index, presence of oronasal fistula, and revision surgeries. All articles were screened for the title, abstract, and full text by 2 reviewers independently and in duplicate. Risk of bias was assessed for RCT using Cochrane's risk of bias tool and the CCT was assessed using the ROBINS-I tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 3545 records identified, 9 studies met the inclusion criteria for qualitative and quantitative synthesis. Eight of the 9 included studies were rated as having moderate to serious risk of bias, and one judged as critical risk of bias. There is very low-quality evidence in favor of secondary grafting performed below 12 years of age compared to secondary grafting performed on or after 12 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Future high-quality RCTs with standardized protocols are necessary to determine the most effective timing for SABG in cleft care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261420691","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:45:09Z","timestamp":1771339509000},"page":"3593-3607","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison on the Success of Secondary Alveolar Bone Grafting Performed Below 12 Years and On or After 12 Years of Age for Patients With Cleft Alveolus: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5422-3289","authenticated-orcid":false,"given":"Rajeswari","family":"Siva","sequence":"first","affiliation":[{"name":"Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8214-4141","authenticated-orcid":false,"given":"Balavenkata Bharathi","family":"Chaturvedula","sequence":"additional","affiliation":[{"name":"Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikrupa","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7809-8111","authenticated-orcid":false,"given":"Badri","family":"Thiruvenkatachari","sequence":"additional","affiliation":[{"name":"Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"87","article-title":"Secondary bone grafting of residual alveolar and palatal clefts","volume":"30","author":"Boyne PJ","year":"1972","unstructured":"Boyne PJ, Sands NR. Secondary bone grafting of residual alveolar and palatal clefts. J Oral Surg. 1972 Feb;30(2):87-92.","journal-title":"J Oral Surg"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000008646"},{"key":"e_1_3_2_4_2","first-page":"41","article-title":"Adolescent facial morphology of early bone grafted cleft lip and palate patients","volume":"16","author":"Friede H","year":"1982","unstructured":"Friede H, Johanson B. Adolescent facial morphology of early bone grafted cleft lip and palate patients. 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