{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:58:39Z","timestamp":1791547119567,"version":"4.3.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,11]]},"abstract":"\n Objective<\/jats:title>\n To evaluate the effectiveness of platelet-rich fibrin (PRF) in the repair of cleft palate (CP), with a primary goal of reducing the occurrence of postoperative palatal fistula formation.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n An RCT was conducted with a 1:1 allocation ratio.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Single-center study conducted in the Department of Plastic & Reconstructive Surgery at a tertiary care center.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n 100 CP repair patients enrolled based on the following inclusion criteria:\n \n \n Non-syndromic CP<\/jats:p>\n <\/jats:list-item>\n \n Age between 1 and 3 years<\/jats:p>\n <\/jats:list-item>\n \n Informed consent.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n \n Participants were randomized using a computer-generated sequence into 2 groups (\n n<\/jats:italic>\n \u2009=\u200950 each). The intervention group received PRF, prepared by Choukroun's method from a 5 to 7\u2005mL blood sample, and applied during surgery. The control group underwent standard CP repair without PRF. Both groups received identical pre & postoperative care.\n <\/jats:p>\n <\/jats:sec>\n \n Main Outcomes<\/jats:title>\n Palatal-fistula formation, wound dehiscence, and postoperative bleeding were assessed.<\/jats:p>\n \n \n No cases of wound dehiscence or postoperative bleeding were observed in either group.<\/jats:p>\n <\/jats:list-item>\n \n Palatal fistula occurred in 3 patients (6%) in the control group (non-PRF), while no cases were observed in the PRF group.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Three palatal fistula cases were observed (3%;\n n<\/jats:italic>\n \u2009=\u2009100), 0% in the PRF group (\n n<\/jats:italic>\n \u2009=\u200950), and 6% in the non-PRF group (\n n<\/jats:italic>\n \u2009=\u200950).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n While PRF appears to be safe, biologically promising, and cost-effective adjunct in CP repair; the study was inconclusive as the small number of fistula occurrence limited ability to statistically substantiate its efficacy in reducing palatal fistula.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10556656261422847","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:04:07Z","timestamp":1776261847000},"page":"3690-3698","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["An RCT Evaluating the Efficacy of Using Platelet-Rich Fibrin (PRF) with Conventional Technique of Cleft Palate Repair"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9668-124X","authenticated-orcid":false,"given":"Soujanya","family":"M.","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Kaher's Jawaharlal Nehru Medical College & KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre, Belagavi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6494-4735","authenticated-orcid":false,"given":"Rajesh S.","family":"Powar","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Kaher's Jawaharlal Nehru Medical College & KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre, Belagavi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_472_20"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijps.IJPS_84_18"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2021.01396."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000548"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1055665619858871"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.07.012."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/138920112800624292"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.08.558"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-018-1087-0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.21608\/ejhm.2019.63231"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-081123"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/njms.NJMS_42_18"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.57197."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.101205"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(88)90044-4."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199106000-00005"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200111000-00011"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199705010-00010"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29191."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000205176.90736.e4"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/1055665618766059"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.81447."},{"issue":"3","key":"e_1_3_3_24_2","first-page":"192","article-title":"Clinical study on fistula incidence of early cleft palate repair","volume":"19","author":"Wang HT","year":"2003","unstructured":"Wang HT, Li F. Clinical study on fistula incidence of early cleft palate repair. Zhonghua Zheng Xing Wai Ke Za Zhi. 2003;19(3):192-194.","journal-title":"Zhonghua Zheng Xing Wai Ke Za Zhi"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102183."},{"key":"e_1_3_3_26_2","volume-title":"Cleft Lip and Palate: A System of Management","author":"Bardach J","year":"1990","unstructured":"Bardach J, Salyer KE. eds. Cleft Lip and Palate: A System of Management. Saunders; 1990."},{"issue":"1","key":"e_1_3_3_27_2","first-page":"101429","article-title":"Presurgical three-dimensional palatal morphology of the hard palate in children with cleft lip and palate","volume":"125","author":"Gemechu JM","year":"2024","unstructured":"Gemechu JM, Patil S, Kale L, Yadav R. Presurgical three-dimensional palatal morphology of the hard palate in children with cleft lip and palate. 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