{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:58:47Z","timestamp":1791547127220,"version":"4.3.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","award":["Qian Ke He Basic Research\u2014ZK[2022] General Progr"],"award-info":[{"award-number":["Qian Ke He Basic Research\u2014ZK[2022] General Progr"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study was to investigate the effect of speech therapy on cerebral morphology in patients with non-syndromic cleft palate with or without cleft lip (NSCP\u2009\u00b1\u2009L) related articulation disorders using structural magnetic resonance imaging technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A prospective pre\u2013post intervention study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>This study was conducted in the Department of Oral and Maxillofacial Surgery and the Medical Imaging Center of a tertiary hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Participants<\/jats:title>\n                    <jats:p>A total of 24 children with NSCP\u2009\u00b1\u2009L, aged 6\u201316 years, who had undergone cleft palate surgery but still presented with articulation disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>These patients received standardized speech therapy and were divided into the before therapy scans group (bTherapy Scans) and after therapy scans group (aTherapy Scans). By using high-resolution T1-weighted cerebral magnetic resonance imaging scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure(s)<\/jats:title>\n                    <jats:p>Cerebral gray matter volume (GMV), cortical thickness (CT), fractal dimension (FD), and sulcus depth (SD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the bTherapy Scans, the aTherapy Scans showed a significant increase in GMV in the left middle frontal gyrus and left medial orbital frontal lobe; a significant increase in CT and FD in the left rostral middle frontal gyrus; and a significant increase in SD in the right lateral orbital frontal lobe region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Speech therapy not only effectively improves the articulatory function of children with NSCP\u2009\u00b1\u2009L-related speech disorders, but its effects may also be associated with structural remodeling of brain regions related to speech motor planning and emotional regulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261427388","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T15:08:39Z","timestamp":1772291319000},"page":"3749-3758","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Morphological Changes Occur in the Brains of Children With Non-Syndromic Cleft Lip and Palate After Speech Therapy"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2535-6683","authenticated-orcid":false,"given":"Yuxiang","family":"Zhai","sequence":"first","affiliation":[{"name":"Capital Medical University"},{"name":"Department of Oral and Maxillofacial Surgery, Stomatology Hospital Affiliated to Zunyi Medical University, Zunyi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Stomatology Hospital Affiliated to Zunyi Medical University, Zunyi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8530-2181","authenticated-orcid":false,"given":"Shenhu","family":"Liang","sequence":"additional","affiliation":[{"name":"People's Hospital of Zhongjiang County"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8357-8075","authenticated-orcid":false,"given":"Renji","family":"Chen","sequence":"additional","affiliation":[{"name":"Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.12.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JCMS.2018.05.006"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1597\/10-237"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-4027"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.110318"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1597\/11-085"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2021.06.002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-021-09496-2"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112144-20220705-00365"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.161.8.753"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.04.009"},{"key":"e_1_3_2_13_2","first-page":"125","article-title":"Establishment and clinical application of Chinese language clear degree","volume":"4","author":"Wang GM","year":"1995","unstructured":"Wang GM, Zhu C, Yuan WH, Jiang LP. 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