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The human homologue of Ds was proposed in a case presenting multiple congenital anomalies associated with the unique feature of a finger-like skin appendage. Since then, several cases have been reported suggesting the occurrence of a disorganization-like (Ds-like) phenotype in humans. Here, we report a case series of 7 patients presenting with the association of orofacial clefts and finger-like skin appendages. These cases, despite the similarities with Ds and amniotic band sequence, may represent a distinct condition within the spectrum of Ds-like, as other cases previously reported in the literature.<\/jats:p>","DOI":"10.1177\/10556656261437279","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T04:55:06Z","timestamp":1774846506000},"page":"4008-4016","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual Association of Orofacial Cleft and Finger-Like Skin Appendages With or Without Constriction Rings: A Disorganization-Like Phenotype?"],"prefix":"10.1177","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4355-6677","authenticated-orcid":false,"given":"Henrique Regonaschi","family":"Serigatto","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5290-3987","authenticated-orcid":false,"given":"Siulan","family":"Vendramini-Pittoli","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"},{"name":"Bauru Medical School, University of S\u00e3o Paulo, Bauru, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-9461","authenticated-orcid":false,"given":"Priscila Padilha","family":"Moura","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-9970","authenticated-orcid":false,"given":"Luiza","family":"Virmond","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"},{"name":"Laborat\u00f3rio Cl\u00ednico, Hospital Israelita Albert Einstein, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6494-2799","authenticated-orcid":false,"given":"Vinicius Contrucci Dantas","family":"Segarra","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1963-7233","authenticated-orcid":false,"given":"Jos\u00e9 Humberto","family":"da Cunha","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-4448","authenticated-orcid":false,"given":"Carla","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Institute of Biosciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4526-3336","authenticated-orcid":false,"given":"Roseli Maria","family":"Zechi-Ceide","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"},{"name":"Bauru Medical School, University of S\u00e3o Paulo, Bauru, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0252-5452","authenticated-orcid":false,"given":"Nancy Mizue","family":"Kokitsu-Nakata","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"},{"name":"Bauru Medical School, University of S\u00e3o Paulo, Bauru, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401370303"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.23.1.212"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(92)90074-t"},{"issue":"5","key":"e_1_3_3_5_2","first-page":"866","article-title":"Two-hit model for sporadic congenital anomalies in mice with the disorganization mutation","volume":"52","author":"Crosby JL","year":"1993","unstructured":"Crosby JL, Varnum DS, Nadeau JH. 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