{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:41:33Z","timestamp":1793716893714,"version":"4.6.1"},"reference-count":46,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the maturation stages of the midpalatal (MPS) and zygomaticomaxillary (ZMS) sutures, as well as the spheno-occipital synchondrosis (SOS), in patients with pycnodysostosis (PYCD) compared with controls, and to explore their associations with age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional study was matched by sex and age with a control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>In a secondary care center for patients with rare diseases in the state of Ceara (Brazil).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>18 participants (9 PYCD, 9 controls).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Sutures were analyzed using cone-beam computed tomography (CBCT) based on established classification systems.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>The stage of suture maturation was the main evaluation parameter. MPS and ZMS were evaluated for fusion stages, while SOS ossification was assessed using a 5-stage maturation scale. Statistical analyses included Pearson's chi-square, Fisher's exact tests, and Spearman's correlations to assess associations between suture stages and demographic or clinical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant differences were observed between the groups in the maturation stages of the ZMS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.009) and MPS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.029), with earlier fusion in patients with PYCD, independent of age. SOS showed no significant differences between groups but exhibited a strong correlation with age (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u2009.001,\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009.727). Associations with sex were observed only for the SOS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u2009.001), indicating earlier fusion in females.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings confirm differences in the fusion stages of the MPS, and ZMS. However, further studies are needed to better understand the influence of sex and age on suture fusion, with age being a particularly significant parameter for the SOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261438345","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:01:47Z","timestamp":1778558507000},"page":"4029-4040","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Craniofacial Suture Maturation in Pycnodysostosis: A CBCT-Based Assessment of the Midpalatal, Zygomaticomaxillary Sutures and the Spheno-Occipital Synchondrosis"],"prefix":"10.1177","volume":"63","author":[{"given":"Cauby Maia","family":"Chaves Junior","sequence":"first","affiliation":[{"name":"Federal University of Ceara (UFC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1939-1219","authenticated-orcid":false,"given":"Pedro Henrique","family":"Moreira Lima","sequence":"additional","affiliation":[{"name":"Federal University of Ceara (UFC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Barbosa","family":"Pereira","sequence":"additional","affiliation":[{"name":"Federal University of Ceara (UFC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luciano Pimenta","family":"Couto","sequence":"additional","affiliation":[{"name":"Division of Pediatric Dentistry, School of Dentistry, Federal University of Ceara, Sobral Campus, Sobral, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlane","family":"Marques Ribeiro","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Albert Sabin Children's Hospital, Fortaleza, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Cevidanes","sequence":"additional","affiliation":[{"name":"University of North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Angelieri","sequence":"additional","affiliation":[{"name":"The University of Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4197-6002","authenticated-orcid":false,"given":"Cristiane S.","family":"Fonteles","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(200001)15:1<57::AID-HUMU12>3.0.CO;2-G"},{"issue":"1","key":"e_1_3_2_3_2","first-page":"132","article-title":"Dental and facial bone abnormalities in pyknodysostosis: CT findings","volume":"28","author":"Fleming KW","year":"2007","unstructured":"Fleming KW, Barest G, Sakai O. 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