{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:48:19Z","timestamp":1782172099676,"version":"3.54.5"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study compares clinical and radiographic outcomes in alveolar bone grafting (ABG) using iliac crest bone graft (ICBG) alone, demineralized bone matrix (DBM) with recombinant human bone morphogenetic protein-2 (rhBMP-2), and ICBG with recombinant human bone morphogenetic protein-2 with demineralized bone matrix (rhBMP2\/DBM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We evaluated differences in clinical success and radiographic bone formation among grafting techniques for secondary alveolar cleft repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design, Setting, and Sample<\/jats:title>\n                    <jats:p>Retrospective cohort study of patients undergoing secondary ABG for cleft alveolus between 2017 and 2023 at a tertiary children's hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Independent Variable<\/jats:title>\n                    <jats:p>Type of grafting technique: ICBG alone, DBM with rhBMP-2, or ICBG with rhBMP-2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Variables<\/jats:title>\n                    <jats:p>The primary outcome was radiographic success (bony bridging on cone-beam computed tomography). Secondary outcomes included vertical bone height and reoperation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Covariates<\/jats:title>\n                    <jats:p>Age, sex, cleft laterality, and graft type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Analyses<\/jats:title>\n                    <jats:p>\n                      Descriptive statistics and comparative analyses were performed. Statistical significance was set at\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 432 patients (527 clefts) were included: 196 ICBG, 284 DBM\u2009+\u2009rhBMP-2, and 47 ICBG\u2009+\u2009rhBMP-2. Radiographic success was highest in the ICBG\u2009+\u2009rhBMP-2 group (89.4%) compared with ICBG (65.3%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.001) and DBM\u2009+\u2009rhBMP-2 (61.6%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Mean vertical bone height was greater in the ICBG\u2009+\u2009rhBMP-2 group (7.4\u2009\u00b1\u20092.6\u2005mm) versus ICBG (4.7\u2009\u00b1\u20091.9\u2005mm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and DBM\u2009+\u2009rhBMP-2 (4.4\u2009\u00b1\u20091.2\u2005mm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>ICBG combined with rhBMP-2 demonstrates improved radiographic bone formation and vertical height compared with alternative grafting strategies, without increasing reoperation rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261461128","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:18:43Z","timestamp":1781860723000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Efficacy of Combined Iliac Crest Bone Graft and Recombinant Human Bone Morphogenetic Protein for Alveolar Bone Grafting"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0088-2991","authenticated-orcid":false,"given":"Artur","family":"Manasyan","sequence":"first","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"Keck School of Medicine of USC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idean","family":"Roohani","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"Keck School of Medicine of USC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0594-7661","authenticated-orcid":false,"given":"Caroline","family":"Kreh","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Kim","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"Keck School of Medicine of USC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Guler","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Firriolo","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"Keck School of Medicine of USC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4712-2476","authenticated-orcid":false,"given":"Laura","family":"Herrera","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"Keck School of Medicine of USC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvee","family":"Turk","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"Keck School of Medicine of USC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-2432","authenticated-orcid":false,"suffix":"III","given":"William P.","family":"Magee","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"Keck School of Medicine of USC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Urata","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"Keck School of Medicine of USC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0030-1420","authenticated-orcid":false,"given":"Jeffrey A.","family":"Hammoudeh","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles"},{"name":"Keck School of Medicine of USC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002778"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003550"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003551"},{"issue":"5","key":"e_1_3_3_5_2","article-title":"Alveolar graft in the cleft lip and palate patient: Review of 104 cases","volume":"19","author":"Luque-Mart\u00edn E","year":"2014","unstructured":"Luque-Mart\u00edn E, Tobella-Camps ML, Rivera-Bar\u00f3 A. 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