{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:07:31Z","timestamp":1789628851023,"version":"build-2803163510"},"reference-count":57,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the prevalence of sleep-disordered breathing (SDB) in children with cleft lip and\/or palate (CL\/P) using validated sleep questionnaires and, where available, sleep studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis guidelines, registered with PROSPERO (CRD42024593761).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A comprehensive search of MEDLINE, Embase, EBM Reviews, Scopus, and Web of Science was conducted up to April 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Seven observational studies were included, involving 1567 syndromic or nonsyndromic children with CL\/P. The weighted mean age was 9.0\u2009\u00b1\u20091.64 years (range: 2-18 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>No clinical interventions were undertaken. SDB was evaluated using validated sleep questionnaires; with polysomnography (PSG) included in 2 studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure(s)<\/jats:title>\n                    <jats:p>Prevalence of SDB in children with CL\/P and associated risk factors, including cleft type and gender.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 546 retrieved articles, 7 studies met the inclusion criteria. All used the Pediatric Sleep Questionnaire, although different cutoff values were applied. Meta-analysis estimated an overall SDB prevalence of 16% (95% CI: 12-21%) with no significant gender differences. The highest prevalence was observed in syndromic CL\/P (32%), while the estimate was lower in nonsyndromic cases (8.8-18%). In studies that included PSG, over 75% of children who screened positive were diagnosed with obstructive sleep apnea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SDB was common in children with CL\/P, particularly in syndromic populations. The limited number of available studies highlighted the need for further research incorporating standardized severity measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261465477","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:36:51Z","timestamp":1783690611000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Sleep-Disordered Breathing in Cleft-Affected Children: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-5426","authenticated-orcid":false,"given":"Tassneem","family":"Elagib","sequence":"first","affiliation":[{"name":"The University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Fan","sequence":"additional","affiliation":[{"name":"The University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8050-2868","authenticated-orcid":false,"given":"Marie A.","family":"Cornelis","sequence":"additional","affiliation":[{"name":"The University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-3259","authenticated-orcid":false,"given":"Paolo M.","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"The University of Melbourne"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3798"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25611"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.985375"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1597\/07-215.1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2021.07.003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2014.07.026"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.10020"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656221147815"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-023-02897-y"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656231193552"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-022-00691-w"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3660"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/1055665619875321"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.4360"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656221119078"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.4172\/plastic-surgery.1000886"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/prs.0000000000000484"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000001119"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.3536"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302104"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.03.001"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656251327881"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17228460"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1389-9457(99)00009-x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.105254"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.01.014"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/xeb.0000000000000054"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/10556656211068306"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5930"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000004294"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200708-135MG"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.1996.00251.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/23.8.1d"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.3.216"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1671"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.sodo.2025.03.005"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2023.103805"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2023.01.017"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1673-0860.2016.11.003"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2021.2023755"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2019.02.021"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-020-02073-6"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.4103\/jnrp.jnrp_428_16"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-011-0279-3"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2014.12.002"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2021.03.009"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.10.024"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25231"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2018.08.033"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.5578\/tt.2467"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2018.05.007"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.70134"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.2319\/070620-610.1"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-023-04511-2"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.09.001"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhad267"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656261465477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10556656261465477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656261465477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:53:04Z","timestamp":1789627984000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10556656261465477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":57,"alternative-id":["10.1177\/10556656261465477"],"URL":"https:\/\/doi.org\/10.1177\/10556656261465477","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"article-number":"10556656261465477"}}