{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T14:04:05Z","timestamp":1785074645084,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Gain insight into the prevalence of mandibular tooth agenesis (MA) in a cleft population in comparison to MA in a non-cleft population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective single-center cohort study with panoramic radiographs analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Frisius Medical Center Leeuwarden, The Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>The study group had 232 individuals with a nonsyndromic cleft lip (CL), cleft lip and palate (CLP) or cleft palate (CP) on treatment by Cleft Team North. The Control group had 350 individuals without an orofacial cleft from the Department of Oral and Maxillofacial Surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>MA per individual and per element type, using the Tooth Agenesis Code.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      10.3% of the cleft group and 4.9% of the control group had MA (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.013). MA was 4 times more prevalent in CP (16.4%) and tended to be 2 times more prevalent in CLP (9.4%) compared to the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.005 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.063, resp.). CL had no MA. The mandibular second premolar (P2) was the most often affected element in both cleft and control groups. Compared to the control group, the left P2 was more often agenetic in CLP and CP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.010 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.003, resp.) and the right P2 only in CP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.014). Unilateral and bilateral CLP had corresponding locations of agenesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tooth agenesis in the mandible seems part of the phenotype of CLP and CP. This suggests common underlying pathways to both orofacial clefts and MA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261471845","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:19:02Z","timestamp":1784899142000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Mandibular Tooth Agenesis in a Nonsyndromic Cleft Population: A Case-Control Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5924-7419","authenticated-orcid":false,"given":"Ineke Caroline","family":"Wolswijk","sequence":"first","affiliation":[{"name":"Frisius Medical Center Leeuwarden"},{"name":"Cleft Team North location Leeuwarden, Frisius Medical Center Leeuwarden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5736-3494","authenticated-orcid":false,"given":"Artur Zdzislaw","family":"Matthews-Brzozowski","sequence":"additional","affiliation":[{"name":"Frisius Medical Center Leeuwarden"},{"name":"Cleft Team North location Leeuwarden, Frisius Medical Center Leeuwarden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8479-4850","authenticated-orcid":false,"given":"Chantal Melissa","family":"Mou\u00ebs-Vink","sequence":"additional","affiliation":[{"name":"Cleft Team North location Leeuwarden, Frisius Medical Center Leeuwarden, the Netherlands"},{"name":"Department of Plastic and Reconstructive Surgery, Frisius Medical Center Leeuwarden, the 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