{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T11:41:40Z","timestamp":1786275700979,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate the long-term psychosocial outcomes in adults with a history of cleft lip and palate (CL\/P) surgical treatment, focusing on social behavior, mental health, education, and employment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A meta-analysis was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, analyzing studies that examined psychosocial objective outcomes in adults who had undergone CL\/P surgery in childhood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Studies were identified through Medline, PubMed, and Cochrane databases, focusing on CL\/P patients compared to control groups without CL\/P.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>The meta-analysis includes 6 studies with a total of 838 adults who had CL\/P, alongside appropriate control groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Surgical intervention for CL\/P during childhood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measure(s)<\/jats:title>\n                    <jats:p>Key outcomes include relationship and marital status, parenthood, highest education level achieved, employment status, and mental health indicators (anxiety and depression symptoms).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adults with CL\/P showed lower rates of marriage and parenthood and exhibited higher levels of singlehood, and anxiety and depression symptoms compared to controls. However, no significant differences were noted in educational or employment achievements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although surgical interventions improve physical outcomes, adults with CL\/P continue to face significant psychosocial challenges, including higher rates of singlehood, increased anxiety and depression symptoms, and lower marriage and parenthood rates. These findings emphasize the need for ongoing psychological support for individuals with CL\/P throughout adulthood. Additionally, this study highlights the importance of further research into the long-term psychosocial effects of CL\/P and the impact of surgical treatment overall.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261475443","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:27:11Z","timestamp":1786026431000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychosocial Health in Adults Who Have Undergone Treatment for Cleft Lip and Palate: A Meta-Analysis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9706-0066","authenticated-orcid":false,"given":"Christophe","family":"Abi Zeid Daou","sequence":"first","affiliation":[{"name":"American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibana","family":"Carapiperis","sequence":"additional","affiliation":[{"name":"American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Khalil","sequence":"additional","affiliation":[{"name":"American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3221-4195","authenticated-orcid":false,"given":"Lana","family":"Ghzayel","sequence":"additional","affiliation":[{"name":"American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita Maria","family":"Jalkh","sequence":"additional","affiliation":[{"name":"American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Dunya","sequence":"additional","affiliation":[{"name":"American University of Beirut Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Patel","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1597\/11-105"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1359104509355021"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-48670-3_6"},{"key":"e_1_3_3_5_2","volume-title":"The psychology of appearance","author":"Rumsey N","year":"2005","unstructured":"Rumsey N. 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