{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:30:26Z","timestamp":1786973426642,"version":"build-2736575974"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1170805"],"award-info":[{"award-number":["1170805"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess the association and interaction between\n                      <jats:italic toggle=\"yes\">MTR<\/jats:italic>\n                      rs1805087 and\n                      <jats:italic toggle=\"yes\">MTRR<\/jats:italic>\n                      rs1801394 polymorphisms and nonsyndromic cleft lip with or without cleft palate (NSCL\u2009\u00b1\u2009P) in a Chilean population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective case-control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rs1805087 and rs1801394 genotypes were extracted from an array for 248 cases and 479 controls. Association analysis was performed by logistic regression for additive, dominant and recessive models and gene-gene interaction was evaluated by a Multifactor Dimensionality Reduction algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No association was detected for\n                      <jats:italic toggle=\"yes\">MTR<\/jats:italic>\n                      rs1805087 (\n                      <jats:italic toggle=\"yes\">p\u2009=\u2009.<\/jats:italic>\n                      870) or\n                      <jats:italic toggle=\"yes\">MTRR<\/jats:italic>\n                      rs1801394 (\n                      <jats:italic toggle=\"yes\">p\u2009=\u2009.<\/jats:italic>\n                      919) and NSCL\/P or for their interaction (\n                      <jats:italic toggle=\"yes\">p\u2009=\u2009.<\/jats:italic>\n                      197).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings in Chile may be explained by no effect of these markers on NSCL\u2009\u00b1\u2009P risk, as was described in other populations. However, we must be cautious with this conclusion due to the low statistical power for association (&lt;10%). Thus, replication studies may include higher sample sizes. In addition, other genes or variants for the methionine cycle as well as the interaction with environmental factors must be considered in future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261478181","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:36:41Z","timestamp":1786721801000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional\n                    <i>MTR<\/i>\n                    and\n                    <i>MTRR<\/i>\n                    Variants Show No Association With Nonsyndromic Cleft Lip With or Without Cleft Palate in Chile"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4175-5536","authenticated-orcid":false,"given":"Jos\u00e9","family":"Suazo","sequence":"first","affiliation":[{"name":"Universidad de Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-9910","authenticated-orcid":false,"given":"Luca","family":"Scapoli","sequence":"additional","affiliation":[{"name":"University of Bologna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Salamanca","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de Chile"},{"name":"Research Center in Dental Sciences (CICO), Dental School, Universidad de La Frontera, Temuco, Chile"},{"name":"Universidad Adventista de Chile, Chill\u00e1n, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Leiva Villagra","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os de Alta Complejidad Dr. Luis Calvo Mckenna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Pantoja","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Borja-Arriaran"},{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Pardo","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universidad de Chile"},{"name":"Unit of Neonatology, Hospital Cl\u00ednico Universidad de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. 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