{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:03:31Z","timestamp":1789977811961,"version":"4.0.1"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Impaired palatal wound healing following cleft palate surgery can compromise functional outcomes, including speech, making their prevention essential. This literature review aims to evaluate the evidence regarding the use of prophylactic antibiotics in cleft palate surgery and to assess whether antibiotic prophylaxis affects palatal wound healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was carried out according to the PRISMA guidelines. Studies regarding the use of prophylactic antibiotics following cleft palate surgery were screened. Impaired palatal wound healing, that is, wound infection, dehiscence, and oronasal fistula, were used as outcome measures. A modified New-Ottawa Scale (NOS) was used for quality appraisal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 382 studies were identified, of which 8 met inclusion criteria; none were excluded based on NOS quality appraisal. In 4 studies comparing antibiotic prophylaxis to no antibiotics, no preventive effect on wound healing problems was demonstrated. Comparisons of prolonged versus shorter antibiotic regimens showed no benefits of prolonged therapy, and the choice of antibiotic agent did not significantly influence outcomes. Notably, one study reported a significant reduction in fistula rates with the use of a local antibiotic soaked palatal pack as an adjunct to standard systemic prophylaxis (2% vs 21%; P &lt; .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Current evidence does not demonstrate that systemic antibiotic prophylaxis affects palatal wound healing following cleft palate surgery. However, evidence-based protocols could only be supported by large clinical prospective trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261481035","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:46:48Z","timestamp":1789739208000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Antibiotic Prophylaxis on Palatal Wound Healing Following Cleft Palate Closure: A Systematic Literature Review"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7763-3293","authenticated-orcid":false,"given":"Lieke","family":"Hofman","sequence":"first","affiliation":[{"name":"University Medical Center Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Ninck Blok","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaheen A. G.","family":"Barsati","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht"},{"name":"VU University Medical Center Amsterdam (VUmc)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom F. W.","family":"Wolfs","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aebele B.","family":"Mink van der Molen","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma C.","family":"Paes","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-98400-7_4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-8124-3_54"},{"key":"e_1_3_2_4_2","unstructured":"Bauer M van der Garde E van Kasteren M Prins J Vos M. SWAB Richtlijn Peri-Operatieve Profylaxe. 2019."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001265"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1597\/03-108.1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1597\/04-083r.1"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(63)80094-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1055665620977363"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1597\/08-082.1"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1597\/11-063"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.207"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2016.09.018"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_2_15_2","unstructured":"GA Wells BSDOJPVWMLPT. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2000."},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00238-007-0116-z"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001324"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000475784.29575.d6"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2286-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005843"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1055665621992653"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000005589"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpra.2024.12.003"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1159455"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1597\/08-187_1"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000011607"},{"issue":"4","key":"e_1_3_2_27_2","first-page":"282","article-title":"Assessing the cost of prophylactic antibiotic use after cleft lip and lip adhesion procedures","volume":"61","author":"Daniels KM","year":"2016","unstructured":"Daniels KM, Lappi MD, Sporn SF, Caillouette CN, Heald R, Meara JG. Assessing the cost of prophylactic antibiotic use after cleft lip and lip adhesion procedures. J Healthc Manag. 2016;61(4):282-289.","journal-title":"J Healthc Manag"},{"key":"e_1_3_2_28_2","unstructured":"Stichting Werkgroep Antibioticabeleid \u2013 SWAP. Plastische chirurgie\u2014Chirurgische profylaxe. https:\/\/children.nl.antibiotica.app\/nl\/node\/390782. 2022."},{"key":"e_1_3_2_29_2","unstructured":"Hofman L Haverkamp SJ Jenniskens K Derksen DAM de Wilde H Kornmann NSS Don Griot P Mink van der Molen AB Paes EC. What is the best technique for cleft palate closure: study protocol for a prospective comparative study in the Netherlands. 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