{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:49:15Z","timestamp":1791834555326,"version":"4.3.4"},"reference-count":15,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"MTF junior investigator in innovation in allograft translational research Grant"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The Cleft Palate Craniofacial Journal"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Donor costal cartilage (DCC) allografts for microtia reconstruction have shown promising clinical results, but characterization of the allografts\u2019 intrinsic properties has yet to be performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Histologically, DCC allografts were compared to autologous costal cartilage (ACC). Biomechanical properties of eight DCC were compared with normative literature values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>University laboratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients, Participants<\/jats:title>\n                    <jats:p>Adolescent and teenage patients undergoing microtia\/anotia reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Histological comparisons between DCC and ACC were performed using Safranin O, Alcian Blue, Masson's Trichrome, and Collagen II-specific staining. Biomechanical evaluation of DCC yielded Young's modulus, ultimate tensile strength, and ultimate compressive strength.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Histologic analysis demonstrated preservation of most collagen content, with a notable reduction in the glycosaminoglycan content of the extracellular matrix in DCC. DCC demonstrated biomechanical performance that overlaps with ACC based on reported literature values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The histologic integrity and biomechanical characteristics reveal DCC may have structural integrity that resembles ACC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10556656261496018","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:05:57Z","timestamp":1791551157000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Histological and Biomechanical Considerations of Donor Costal Cartilage Allografts for Total Ear Reconstruction"],"prefix":"10.1177","author":[{"given":"Arya A.","family":"Sherafat","sequence":"first","affiliation":[{"name":"University of California, Irvine Medical Center"},{"name":"School of Medicine, University of California, Riverside"},{"name":"Center for Tissue Engineering, University of California, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Doan","sequence":"additional","affiliation":[{"name":"University of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashton","family":"Rosenbloom","sequence":"additional","affiliation":[{"name":"University of California, Irvine Medical Center"},{"name":"Center for Tissue Engineering, University of California, Orange, CA, USA"},{"name":"Department of Surgery, New York Presbyterian - Brooklyn Methodist Hospital, Brooklyn, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Donahue","sequence":"additional","affiliation":[{"name":"University of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingirirai Michael","family":"Chaokma","sequence":"additional","affiliation":[{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriacos A.","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"University of California, Irvine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ziegler","sequence":"additional","affiliation":[{"name":"University of California, Irvine Medical Center"},{"name":"Center for Tissue Engineering, University of California, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Widgerow","sequence":"additional","affiliation":[{"name":"University of California, Irvine Medical Center"},{"name":"Center for Tissue Engineering, University of California, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahim","family":"Esfandyarpour","sequence":"additional","affiliation":[{"name":"University of California, Irvine"},{"name":"University of California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles J.","family":"Pfaff","sequence":"additional","affiliation":[{"name":"University of California, Irvine Medical Center"},{"name":"Center for Tissue Engineering, University of California, Orange, CA, USA"},{"name":"Children's Hospital of Orange County"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34352"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.scs.0000168761.46700.dc"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2006.01.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000007400"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000003518"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000008845"},{"key":"e_1_3_3_8_2","volume-title":"Total ear reconstruction using homograft costal cartilage","author":"Bastidas N.","year":"2022","unstructured":"Bastidas N. Total ear reconstruction using homograft costal cartilage. MTF Biologics; 2022."},{"key":"e_1_3_3_9_2","unstructured":"Instron. n.d. Universal testing systems. Retrieved June 28 2026 from https:\/\/www.instron.com\/en\/products\/testing-systems\/universal-testing-systems\/."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93176-x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2020.109688"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archfacial.2011.54"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.28820"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.10.020"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000003518"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/648459"}],"container-title":["The Cleft Palate Craniofacial Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656261496018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10556656261496018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10556656261496018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T19:21:48Z","timestamp":1791832908000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10556656261496018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":15,"alternative-id":["10.1177\/10556656261496018"],"URL":"https:\/\/doi.org\/10.1177\/10556656261496018","relation":{},"ISSN":["1055-6656","1545-1569"],"issn-type":[{"value":"1055-6656","type":"print"},{"value":"1545-1569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"article-number":"10556656261496018"}}