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In the vertebrate, there are separate neuromodulators that respond to threats, reward anticipation, novelty, and attentional effort. However, each of these neuromodulatory systems has a similar effect, that is, to cause an organism to be decisive when environmental conditions call for such actions, and allow the organism to be more exploratory when there are no pressing events. In this article, it is proposed that principles of the neuromodulatory system could provide a framework for controlling artificial agents that may improve current artificial agent behavior. 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