{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:21:09Z","timestamp":1777522869714,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007161","name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado, Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009347","name":"instituto nacional de psiquiatr\u00eda ram\u00f3n de la fuente mu\u00f1iz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Adaptive Behavior"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Inhalant abuse is a global issue with major behavioral, cognitive, and social consequences. Some effects of this abuse are observed in memory deficits, but the organism\u2013environment interactions are poorly understood. We propose that studying environmental enrichment (EE) in animal models allows the elucidation of adaptive behavior mechanisms to face harmful effects, as well as plausible translational interventions; however, the effects of the different elements that comprise the complexity of EE must be determined. In this work, we measured the effects of housing under five environments for 4 weeks on memory impairments induced by the repeated administration of toluene in mice (4000 ppm, 30 min\/day for 4 weeks). Recognition memory was recovered after housing in a complete enriched environment involving voluntary exercise with running wheels, cognitive stimulation with objects to explore, and social interaction. However, enrichment with only voluntary exercise in social conditions produced a significant memory recovery. In addition, EE in isolation showed fewer beneficial effects, while cognitive stimulation, even under social conditions, did not reverse the memory impairment by itself. We argue that physical exercise and social interaction could derive in cognitive enhancement and be used to advise on psychosocial interventions.<\/jats:p>","DOI":"10.1177\/1059712319854361","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T06:42:36Z","timestamp":1560321756000},"page":"277-282","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Physical exercise and social interaction in complex environments reverse memory deficits induced by inhalants"],"prefix":"10.1177","volume":"27","author":[{"given":"Roberto E","family":"Mercadillo","sequence":"first","affiliation":[{"name":"Area of Neuroscience, Department of Biology of Reproduction, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, Ciudad de M\u00e9xico, M\u00e9xico"},{"name":"CONACYT, Ciudad de M\u00e9xico, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Mosco-Aquino","sequence":"additional","affiliation":[{"name":"Area of Neuroscience, Department of Biology of Reproduction, Universidad Aut\u00f3noma Metropolitana-Iztapalapa, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5722-7543","authenticated-orcid":false,"given":"Nayeli","family":"P\u00e1ez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Ciudad de M\u00e9xico, M\u00e9xico"},{"name":"Laboratorio Integrativo para el Estudio de Sustancias Inhalables Adictivas, Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"bibr1-1059712319854361","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2006.04.001"},{"key":"bibr2-1059712319854361","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.10.004"},{"key":"bibr3-1059712319854361","doi-asserted-by":"publisher","DOI":"10.3109\/10826084.2011.580169"},{"key":"bibr4-1059712319854361","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.03.017"},{"key":"bibr5-1059712319854361","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.1.1"},{"key":"bibr6-1059712319854361","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.121.4.679"},{"key":"bibr7-1059712319854361","first-page":"18","volume":"6","author":"Howard M. 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