{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T10:39:41Z","timestamp":1782729581472,"version":"3.54.5"},"reference-count":88,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To review information on desloratadine, a nonsedating antihistamine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SOURCES:<\/jats:title>\n                    <jats:p>An English-language MEDLINE search was conducted (1966\u2013July 2002). References of identified articles were subsequently reviewed for additional data. Schering Corporation provided unpublished information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY SELECTION\/DATA EXTRACTION:<\/jats:title>\n                    <jats:p>Articles and abstracts pertaining to desloratadine were considered for inclusion, with emphasis on randomized, placebo-controlled, double-blind trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATA SYNTHESIS:<\/jats:title>\n                    <jats:p>Desloratadine is approved for the treatment of symptoms associated with seasonal allergic rhinitis (SAR), perennial allergic rhinitis (PAR), and chronic idiopathic urticaria (CIU) in patients aged \u226512 years. In placebo-controlled trials, desloratadine demonstrated superior efficacy as a once-daily treatment of SAR, PAR, and CIU. Data suggest that desloratadine has antiinflammatory and decongestant activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Desloratadine appears to be a \u201cme-too\u201d agent, with no major differences compared with other second-generation antihistamines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/106002800303700216","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T07:39:55Z","timestamp":1483688395000},"page":"237-246","source":"Crossref","is-referenced-by-count":14,"title":["Desloratadine: A Nonsedating Antihistamine"],"prefix":"10.1177","volume":"37","author":[{"given":"Lynn","family":"Limon","sequence":"first","affiliation":[{"name":"Lynn Limon PharmD, Drug Information Specialist, Department of Pharmacy Services, Virginia Commonwealth University Health System, Medical College of Virginia Hospitals and Physicians, Richmond, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise R","family":"Kockler","sequence":"additional","affiliation":[{"name":"Denise R Kockler PharmD, Director, Drug Information Service, Department of Pharmacy Services, Virginia Commonwealth University Health System, Medical College of Virginia Hospitals and Physicians"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,2,1]]},"reference":[{"key":"bibr1-106002800303700216","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161020-00006"},{"key":"bibr2-106002800303700216","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199957010-00004"},{"key":"bibr3-106002800303700216","unstructured":"Seldane and generic terfenadine withdrawn from market. 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