{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:56:52Z","timestamp":1777420612322,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T00:00:00Z","timestamp":1384214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Background: Methadone is commonly prescribed for children with opioid abstinence syndrome (OAS) as a taper schedule over several days to weeks. The Medication Taper Complexity Score (MTCS) was developed to evaluate outpatient methadone tapers. Objective: To further validate the MTCS and determine if it is a reliable tool for clinicians to use to assess the complexity of methadone tapers for OAS. Methods: An expert panel of pediatric clinical pharmacists was convened. Panel members were provided 9 methadone tapers (ie, \u201ceasy,\u201d \u201cmedium,\u201d and \u201cdifficult\u201d) to determine construct and face validity of the MTCS. The primary objective was to further establish reliability and construct\/face validity of the MTCS. The secondary objective was to assess the reliability of the MTCS within and between tapers. Instrument reliability was assessed using a Pearson correlation coefficient; with 0.8 as the minimum acceptable coefficient. Construct (divergent) validity was assessed via a repeated-measures ANOVA analysis (Bonferroni post hoc analyses) of the mean scores provided by panel members. Results: Six panel members were recruited from various geographical locations. Panel members had 18.3 \u00b1 5.5 years of experience, with practice expertise in general pediatrics, hematology\/oncology, and the pediatric and neonatal intensive care unit. The MTCS had a reliability coefficient of .9949. There was vivid discrimination between the easy, medium, and difficult tapers; P = .001. The panel recommended minor modifications to the MTCS. Conclusions: The MTCS was found to be a reliable and valid tool. Overall, the panel felt that the MTCS was easy to use and had potential applications in both practice and research.<\/jats:p>","DOI":"10.1177\/1060028013512110","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T22:22:19Z","timestamp":1391120539000},"page":"187-195","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["External Validation of the Medication Taper Complexity Score for Methadone Tapers in Children With Opioid Abstinence Syndrome"],"prefix":"10.1177","volume":"48","author":[{"given":"Peter N.","family":"Johnson","sequence":"first","affiliation":[{"name":"University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie L.","family":"Miller","sequence":"additional","affiliation":[{"name":"University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy M.","family":"Hagemann","sequence":"additional","affiliation":[{"name":"University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Castro","sequence":"additional","affiliation":[{"name":"University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Harrison","sequence":"additional","affiliation":[{"name":"University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,11,12]]},"reference":[{"key":"bibr1-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199405000-00009"},{"key":"bibr2-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199901000-00052"},{"key":"bibr3-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C324"},{"key":"bibr4-1060028013512110","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1542\/peds.101.6.1079","volume":"101","author":"American Academy of Pediatrics, Committee on Drugs","year":"1998","journal-title":"Pediatrics"},{"key":"bibr5-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318181600d"},{"key":"bibr6-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0489"},{"key":"bibr7-1060028013512110","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2010.0011"},{"key":"bibr8-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M161"},{"key":"bibr9-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1592\/phco.21.20.1566.34471"},{"key":"bibr10-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.01153.x"},{"key":"bibr11-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1097\/00130478-200110000-00009"},{"key":"bibr12-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000202395.94542.3e"},{"key":"bibr13-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1097\/00130478-200010000-00005"},{"key":"bibr14-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1007\/BF01711905"},{"key":"bibr15-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199011000-00024"},{"key":"bibr16-1060028013512110","doi-asserted-by":"publisher","DOI":"10.3233\/PIC-2012-018"},{"key":"bibr17-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181fe38f5"},{"key":"bibr18-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1177\/088506669601100504"},{"key":"bibr19-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2011.12.002"},{"key":"bibr20-1060028013512110","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D479"},{"key":"bibr21-1060028013512110","unstructured":"Stata Statistical Software [computer program]. 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