{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:58:51Z","timestamp":1777420731339,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T00:00:00Z","timestamp":1395964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Objective:To evaluate and review the literature surrounding the potential protective benefit of tetracyclines, particularly doxycycline, in reducing Clostridium difficile infection (CDI) acquisition. Data Sources: MEDLINE\/PubMed, Google Scholar, and International Pharmaceutical Abstracts were searched through January 2014 using the search terms doxycycline, tetracycline, and Clostridium difficile. Study Selection and Data Extraction: Relevant studies, case reports, and review articles were screened for inclusion. Bibliographies of articles were extensively reviewed for additional sources. Data Synthesis: Doxycycline is a second-generation tetracycline antibiotic indicated for use in a variety of clinical syndromes and has activity against aerobic Gram-positive and -negative, anaerobic, and atypical bacteria as well as protozoan parasites. Although not used therapeutically to treat CDI, doxycycline may prevent or attenuate the virulence factors of toxigenic C difficile. Current literature does not indicate an increased risk of development of CDI with doxycycline use. In 3 retrospective studies, the use of doxycycline was associated with a protective effect. Conclusions: Doxycycline has been shown to have potential protective effects against the development of CDI. Although further randomized placebo-controlled studies are needed, available data suggest that the use of doxycycline in place of alternative antimicrobials, when appropriate, may be a useful antimicrobial stewardship strategy aimed at reducing the incidence of CDI.<\/jats:p>","DOI":"10.1177\/1060028014528792","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T21:49:00Z","timestamp":1396043340000},"page":"772-776","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Role of Doxycycline in\n                    <i>Clostridium difficile<\/i>\n                    Infection Acquisition"],"prefix":"10.1177","volume":"48","author":[{"given":"R. Brigg","family":"Turner","sequence":"first","affiliation":[{"name":"Pacific University Oregon School of Pharmacy, Hillsboro, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen B.","family":"Smith","sequence":"additional","affiliation":[{"name":"St Louis College of Pharmacy, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay L.","family":"Martello","sequence":"additional","affiliation":[{"name":"WVU School of Pharmacy, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Slain","sequence":"additional","affiliation":[{"name":"WVU School of Pharmacy, Morgantown, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,3,28]]},"reference":[{"key":"bibr1-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.4"},{"key":"bibr2-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1086\/651706"},{"key":"bibr3-1060028014528792","doi-asserted-by":"publisher","DOI":"10.3201\/eid1305.061124"},{"key":"bibr4-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr253"},{"key":"bibr5-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440340035003"},{"key":"bibr6-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(98)90019-6"},{"key":"bibr7-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Q080"},{"key":"bibr8-1060028014528792","first-page":"6","volume":"149","author":"Bartlett JG","year":"1981","journal-title":"Johns Hopkins Med J"},{"key":"bibr9-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/20.Supplement_2.S263"},{"key":"bibr10-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1177\/0897190013499524"},{"key":"bibr11-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.1.43"},{"key":"bibr12-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92581-3"},{"key":"bibr13-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2011.06.006"},{"key":"bibr14-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.1.127"},{"key":"bibr15-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1086\/524320"},{"key":"bibr16-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis457"},{"key":"bibr17-1060028014528792","first-page":"276","volume":"255","author":"Barthram JD","year":"1995","journal-title":"Pharm J"},{"key":"bibr18-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.071812"},{"key":"bibr19-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-194"},{"key":"bibr20-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1086\/502539"},{"key":"bibr21-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1086\/502602"},{"key":"bibr22-1060028014528792","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq038"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028014528792","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028014528792","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028014528792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:02Z","timestamp":1777374902000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1060028014528792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,28]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1177\/1060028014528792"],"URL":"https:\/\/doi.org\/10.1177\/1060028014528792","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,28]]}}}