{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:59:07Z","timestamp":1777420747750,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Objective:To alert clinicians to a serious complication from a commonly prescribed medication, moxifloxacin. Case Summary: A 65-year-old male, septic, hemodialysis patient developed thrombocytopenia following exposure to vancomycin, ceftazidime, and moxifloxacin. Drug-specific immunoglobulin testing showed positive autoantibodies against only moxifloxacin, and the probability stratification proposed by Naranjo et al would give this case a score of 7\u2014a probable association between moxifloxacin and the adverse event. Discussion: Idiopathic thrombocytopenic purpura (ITP) results in immune-mediated platelet destruction, with bleeding risk frequently manifested by purpuric skin and mucosal lesions. Although many drugs are associated with ITP, moxifloxacin has only been characterized in 2 previous case reports. This is the first case report where specific immunoglobulin antibody testing showed a positive association between ITP and moxifloxacin. Conclusions: Moxifloxacin is a commonly prescribed medication because of its wide spectrum of activity, high bioavailability, and convenient dose schedule. Clinicians need to be aware of this little-known side effect of this commonly prescribed antibiotic.<\/jats:p>","DOI":"10.1177\/1060028014529929","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T01:27:08Z","timestamp":1396315628000},"page":"919-922","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Moxifloxacin-Induced Immune-Mediated Thrombocytopenia in a Chronic Kidney Disease Patient Receiving Hemodialysis"],"prefix":"10.1177","volume":"48","author":[{"given":"Jonathan F.","family":"Mailman","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Stigant","sequence":"additional","affiliation":[{"name":"Royal Jubilee Hospital\u2013Vancouver Island Health Authority, Victoria, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Martinusen","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada"},{"name":"Royal Jubilee Hospital\u2013Vancouver Island Health Authority, Victoria, BC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,3,31]]},"reference":[{"key":"bibr1-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03360.x"},{"key":"bibr2-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1370-4"},{"key":"bibr3-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12052"},{"key":"bibr4-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.9.2714.2714"},{"key":"bibr5-1060028014529929","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200629080-00008"},{"key":"bibr6-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc070907"},{"key":"bibr7-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr522"},{"key":"bibr8-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-006-9052-1"},{"key":"bibr9-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/459140"},{"key":"bibr10-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2012-007501"},{"key":"bibr11-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2009.01996.x"},{"key":"bibr12-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm141"},{"key":"bibr13-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"bibr14-1060028014529929","first-page":"283","volume":"39","author":"Huh HJ","year":"2009","journal-title":"Ann Clin Lab Sci"},{"key":"bibr15-1060028014529929","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.130"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028014529929","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028014529929","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028014529929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:05Z","timestamp":1777374905000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1060028014529929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,31]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1177\/1060028014529929"],"URL":"https:\/\/doi.org\/10.1177\/1060028014529929","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,31]]}}}