{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:59:34Z","timestamp":1777420774421,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T00:00:00Z","timestamp":1401235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To review the pharmacology, pharmacokinetics, clinical efficacy, and safety of the newly approved drug, teduglutide, for the treatment of short bowel syndrome (SBS).\n                    <jats:bold>Data Sources:<\/jats:bold>\n                    Literature was retrieved through PubMed (1966-March 2014) using the search term\n                    <jats:italic toggle=\"yes\">teduglutide<\/jats:italic>\n                    . The authors applied the filters Humans and English language, resulting in 47 publications.\n                    <jats:bold>Study Selection and Data Extraction:<\/jats:bold>\n                    The authors reviewed the 47 citations to extract those that were published clinical trials. Bibliographies of recent review articles and editorials were evaluated for additional pertinent publications for inclusion. The methods and results from each of the trials were extracted.\n                    <jats:bold>Data Synthesis:<\/jats:bold>\n                    Teduglutide has been studied in SBS in 3 phase III trials. Teduglutide decreases parenteral nutrition (PN) volume requirements, with 1 study showing a reduction of 4.4 \u00b1 3.8 L\/wk with teduglutide 0.05 mg\/kg versus 2.3 \u00b1 2.7 L\/wk with placebo;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001. In another study, teduglutide improved graded response scores, which are based on the intensity and duration of the reduction of PN use (16\/35 assigned to teduglutide 0.05 mg\/kg vs 1\/16 assigned to placebo;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.007). The dosing range studies have indicated that the optimal dose of teduglutide is 0.05 mg\/kg daily subcutaneously. There are a number of adverse effects reported in the trials, including abdominal pain or distention, injection site reactions, nausea, headaches, and fluid overload among others. There is also a concern for the development of malignancy with teduglutide, and therefore, it is not recommended in patients with active gastrointestinal malignancies.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Overall, teduglutide appears to be a promising agent for the treatment of SBS.\n                  <\/jats:p>","DOI":"10.1177\/1060028014537468","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:53:20Z","timestamp":1401324800000},"page":"1209-1213","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Teduglutide for the Treatment of Short Bowel Syndrome"],"prefix":"10.1177","volume":"48","author":[{"given":"Sheila M.","family":"Wilhelm","sequence":"first","affiliation":[{"name":"Wayne State University, Detroit, MI, USA"},{"name":"Harper University Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Lipari","sequence":"additional","affiliation":[{"name":"Wayne State University, Detroit, MI, USA"},{"name":"St John Hospital and Medical Center, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice K.","family":"Kulik","sequence":"additional","affiliation":[{"name":"Wayne State University, Detroit, MI, USA"},{"name":"St John Hospital and Medical Center, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramodini B.","family":"Kale-Pradhan","sequence":"additional","affiliation":[{"name":"Wayne State University, Detroit, MI, USA"},{"name":"St John Hospital and Medical Center, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,5,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.10.002"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113512678"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G419."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.02.008."},{"key":"e_1_3_2_6_2","unstructured":"Gattex (teduglutide) [product information]. http:\/\/www.npsp.com\/file_depot\/0-10000000\/0-10000\/262\/folder\/2023\/Gattex_PI-IFU_FINAL_2012-12-21.pdf. Accessed March 4 2014."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1455-7."},{"key":"e_1_3_2_8_2","unstructured":"Tappenden KA Bartholome AL Demchyshyn L . ALX-0600 a glucagon-like peptide-2 (GLP-2) analog enhances intestinal structure and function in patients with short bowel syndrome. Paper presented at: Digestive Disease Week; May 19-22 2002; San Francisco CA."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.061440."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.218271."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.007."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.029."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607111414431."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182828f57."},{"key":"e_1_3_2_15_2","unstructured":"NPS Pharmaceuticals. Pioneering and delivering therapies that transform the lives of patients with rare diseases worldwide. http:\/\/www.npsp.com\/file_depot\/0-10000000\/0-10000\/262\/folder\/2023\/Investor+Slide+Deck.pdf. Accessed March 4 2014."},{"key":"e_1_3_2_16_2","unstructured":"Herper M. Inside the pricing of a $300 000-a-year drug. http:\/\/www.forbes.com\/sites\/matthewherper\/2013\/01\/03\/inside-the-pricing-of-a-300000-a-year-drug\/. Accessed March 4 2014."},{"key":"e_1_3_2_17_2","first-page":"255","article-title":"Utilization and costs to families for health care services each year","volume":"28","author":"Piamjariyakul U","year":"2010","unstructured":"Piamjariyakul U, Ross VM, Yadrich DM, Williams AR, Howard L, Smith CE. Complex home care: part I. Utilization and costs to families for health care services each year. 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