{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:45Z","timestamp":1777420845811,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>Objective: Trigeminal neuralgia (TN) is a neuropathic pain condition affecting one or more branches of the trigeminal nerve. It is characterized by unilateral, sudden, shock-like, and brief painful attacks, which follow the distribution of trigeminal nerve branches, and with no other accompanying sensorimotor or autonomic signs and symptoms. Current guidelines stipulate which therapies represent first-, second-, and third-line treatments for TN, but there is a consistent mismatch between the therapeutic guidelines and the patient\u2019s preferences and expectations. Case Summary: We report on 2 patients with classical TN in whom conventional drugs for TN were not tolerated. In these patients, treatment with 5% lidocaine medicated plaster (LMP) resulted in reduction of pain intensity and the number of pain paroxysms. Discussion: LMP is known to block the sodium channels on peripheral nerves and may cause a selective and partial block of A\u03b4 and C fibers. According to the TN ignition hypothesis, blockage of peripheral afferents by LMP may reduce pain paroxysms. The effect of LMP may outlast the pharmacokinetics of the drug by reducing pain amplification mechanisms in the central nervous system. LMP has limited or no systemic side effects. Conclusions: LMP may be an effective and well-tolerated treatment option for TN in those patients who do not tolerate or who refuse other therapies. Future randomized controlled studies should better address this issue.<\/jats:p>","DOI":"10.1177\/1060028014544166","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:35:17Z","timestamp":1406594117000},"page":"1521-1524","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of 5% Lidocaine Medicated Plaster on Pain Intensity and Paroxysms in Classical Trigeminal Neuralgia"],"prefix":"10.1177","volume":"48","author":[{"given":"Stefano","family":"Tamburin","sequence":"first","affiliation":[{"name":"University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Schweiger","sequence":"additional","affiliation":[{"name":"University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Magrinelli","sequence":"additional","affiliation":[{"name":"University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paola","family":"Brugnoli","sequence":"additional","affiliation":[{"name":"University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampietro","family":"Zanette","sequence":"additional","affiliation":[{"name":"Pederzoli Hospital, Peschiera del Garda, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Polati","sequence":"additional","affiliation":[{"name":"University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,7,28]]},"reference":[{"key":"bibr1-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000326598.83183.04"},{"key":"bibr2-1060028014544166","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1468-2982.2003.00824.x","volume":"24","author":"Headache Classification Subcommittee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr3-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2013-000536"},{"key":"bibr4-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.02999.x"},{"issue":"4","key":"bibr5-1060028014544166","first-page":"CD005451","author":"Wiffen PJ","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr6-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-34"},{"key":"bibr7-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01675.x"},{"key":"bibr8-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01561.x"},{"key":"bibr9-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e318158011a"},{"key":"bibr10-1060028014544166","first-page":"201","volume":"3","author":"Lemos L","year":"2010","journal-title":"J Pain Res"},{"key":"bibr11-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1097\/00002508-200201000-00002"},{"key":"bibr12-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014532789"},{"key":"bibr13-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.08.020"},{"key":"bibr14-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1002\/jps.10133"},{"key":"bibr15-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1A185"},{"key":"bibr16-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Q013"},{"key":"bibr17-1060028014544166","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.02.009"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028014544166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028014544166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028014544166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:21Z","timestamp":1777374921000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1060028014544166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,28]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1177\/1060028014544166"],"URL":"https:\/\/doi.org\/10.1177\/1060028014544166","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,28]]}}}