{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:01:56Z","timestamp":1777420916669,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T00:00:00Z","timestamp":1414454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Objective: To evaluate the literature describing acetaminophen use in treatment of patent ductus arteriosus (PDA). Data Sources: Searches were conducted in MEDLINE with full text (EBSCOhost; 1946 to September 2014) using the search terms acetaminophen, paracetamol, and patent ductus arteriosus. The references of identified articles were reviewed to identify other relevant articles. Study Selection and Data Extraction: Human clinical trials and case reports limited to the English language were reviewed. In all, 12 case reports and 2 randomized, controlled clinical trials explored the use of acetaminophen in treating PDA. Data Synthesis: The case reports described the use of oral or intravenous acetaminophen in patients with contraindications to or who had previously failed nonsteroidal anti-inflammatory drug therapy for PDA. More than 76% of patients achieved successful PDA closure in reported cases. The clinical trials compared the efficacy of oral acetaminophen versus oral ibuprofen in preterm infants. Acetaminophen was noninferior to ibuprofen, with closure rates from 72.5% to 81.2%. The acetaminophen dose used in most case series and trials was 15 mg\/kg dose every 6 hours for 3 days. Acetaminophen therapy was well tolerated, with only a few incidents of elevated liver enzymes being reported. Conclusion: Oral acetaminophen is an alternative to PDA therapy in preterm infants when indomethacin\/ibuprofen is not effective or is contraindicated, and it may be considered before surgical ligation.<\/jats:p>","DOI":"10.1177\/1060028014557564","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:29:30Z","timestamp":1414542570000},"page":"241-246","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Acetaminophen for Patent Ductus Arteriosus"],"prefix":"10.1177","volume":"49","author":[{"given":"Jennifer","family":"Le","sequence":"first","affiliation":[{"name":"Southwestern Oklahoma State University College of Pharmacy, Weatherford, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Gales","sequence":"additional","affiliation":[{"name":"Southwestern Oklahoma State University College of Pharmacy, Weatherford, OK, USA"},{"name":"Integris Baptist Medical Center, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry J.","family":"Gales","sequence":"additional","affiliation":[{"name":"Southwestern Oklahoma State University College of Pharmacy, Weatherford, OK, USA"},{"name":"Integris Baptist Medical Center, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,10,28]]},"reference":[{"key":"bibr1-1060028014557564","unstructured":"US Department of Health & Human Services. National Institutes of Health, National Heart, Lung, and Blood Institute. What is patent ductus arteriosus? http:\/\/www.nhl-bi.nih.gov\/health\/health-topics\/topics\/pda\/. Accessed August 21, 2014."},{"key":"bibr2-1060028014557564","unstructured":"Mayo Clinic. Diseases and conditions: patent ductus arteriosus. http:\/\/www.mayoclinic.org\/diseases-conditions\/patent-ductus-arteriosus\/basics\/treatment\/con-20028530. Accessed August 21, 2014."},{"key":"bibr3-1060028014557564","first-page":"1","volume":"2014","author":"Sekar KC","journal-title":"Medscape Educ"},{"key":"bibr4-1060028014557564","unstructured":"Merck Sharp & Dohme Corp. Merck manuals: patent ductus arteriosus (PDA). http:\/\/www.merckmanuals.com\/professional\/pediatrics\/congenital_cardiovascular_anomalies\/patent_ductus_arteriosus_pda.html?qt=patent%20ductus%20arteriosus&alt=sh%23v1096376. Accessed August 21, 2014."},{"key":"bibr5-1060028014557564","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-12.3.147"},{"key":"bibr6-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.092734"},{"key":"bibr7-1060028014557564","unstructured":"Indocin I.V. (indomethacin for injection) [product information]. Whitehouse Station, NJ: Lundbeck Inc; 2009."},{"key":"bibr8-1060028014557564","unstructured":"NeoProfen (ibuprofen lysine) injection [product information]. Lebanon, NJ: Recordati Rare Diseases Inc; 2013."},{"key":"bibr9-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003481.pub5"},{"key":"bibr10-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300532"},{"key":"bibr11-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.10.008"},{"key":"bibr12-1060028014557564","doi-asserted-by":"publisher","DOI":"10.2165\/00128072-200305060-00004"},{"key":"bibr13-1060028014557564","unstructured":"Acetaminophen: NEOFAX 2011\n                      . 24th ed. Montvale, NJ: Thompson Reuters; 2011."},{"key":"bibr14-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02764.x"},{"key":"bibr15-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0359"},{"key":"bibr16-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302044"},{"key":"bibr17-1060028014557564","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.123164"},{"key":"bibr18-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0770-9"},{"key":"bibr19-1060028014557564","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4847.109245"},{"key":"bibr20-1060028014557564","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.871630"},{"key":"bibr21-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.96"},{"key":"bibr22-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1159\/000345337"},{"key":"bibr23-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1159\/000352068"},{"key":"bibr24-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1159\/000353451"},{"key":"bibr25-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1159\/000348568"},{"key":"bibr26-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-40-21"},{"key":"bibr27-1060028014557564","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.755162"},{"key":"bibr28-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.11.008"},{"key":"bibr29-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.04.025"},{"key":"bibr30-1060028014557564","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077888"},{"key":"bibr31-1060028014557564","unstructured":"Zekai Tahir Burak Maternity and Teaching Hospital. Serum level measurement of oral paracetamol and oral ibuprofen for patent ductus arteriosus treatment in preterm infants [NLM identifier: NCT01544972]. http:\/\/www.clinicaltrialssearch.org\/serum-level-measurement-of-oral-paracetamol-and-oral-ibup-rofen-for-patent-ductus-arteriosus-treatment-in-preterm-infants-nct01544972.html. Accessed October 13, 2014."},{"key":"bibr32-1060028014557564","unstructured":"Hammerman C, Shaare Zedek Medical Center. Paracetamol and patent ductus arteriosus (PDA) [NLM identifier: NCT01291654]. http:\/\/clinicaltrials.gov\/show\/NCT01291654. Accessed October 13, 2014."},{"key":"bibr33-1060028014557564","unstructured":"Aikio O, University of Oulu. The Preterm Infants\u2019 Paracetamol Study (PreParaS) [NLM identifier: NCT01938261]. http:\/\/clinicaltrials.gov\/show\/NCT01938261. Accessed October 13, 2014."},{"key":"bibr34-1060028014557564","unstructured":"Lago P. Paracetamol vs Ibuprofen for PDA Closure in Preterm Infants. (PARIDA) [NLM identifier: NCT02056223]. http:\/\/clinicaltrials.gov\/ct2\/show\/NCT02056223. 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