{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:02:40Z","timestamp":1777420960113,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T00:00:00Z","timestamp":1422403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:p>Background: Ethanol lock therapy (ELT) has emerged as an effective method for the prevention and treatment of central line-associated bloodstream infections (CLABSIs), but the safety of ELT in infants has not been established. Objective: The objective of this study was to determine blood alcohol concentration (BAC) and evidence of hepatic injury in infants after infusing a small one-time dose of ethanol, equivalent to the volume that would be flushed through the central venous catheter (CVC) after ELT is completed. Methods: This was a prospective pilot study in infants weighing \u22646 kg with and without liver dysfunction who had a CVC. The primary end points were 5-minute and 1-hour BACs after a 0.4-mL dose of 70% ethanol was flushed through the CVC. Acceptable BACs were defined as &lt;0.025% at 5 minutes and &lt;0.01% at 1 hour. The secondary end point was evidence of hepatic injury, defined as a change of greater than 2 times the upper limit of normal of any component in the hepatic panel in patients with a normal baseline panel or doubling of any component in the hepatic panel in patients with an abnormal baseline panel (aspartate aminotransferase, alanine transaminase, total or direct bilirubin, gamma-glutamyl transferase, or alkaline phosphatase). Results: A total of 10 patients were included for analysis, with a mean age and weight of 3.5 \u00b1 2.4 months and 4.5 \u00b1 0.9 kg, respectively. All patients had acceptable BACs and no evidence of hepatic injury. In 8 patients, 5-minute BACs were undetectable; BACs of the other 2 patients were 0.011%. One-hour BACs in all patients were undetectable. Conclusions: Flushing ELT resulted in acceptable BACs and no evidence of hepatic injury in this patient cohort. Further studies are needed to investigate the long-term safety and efficacy of ethanol infusion after ELT in this patient population for the prevention and treatment of CLABSIs.<\/jats:p>","DOI":"10.1177\/1060028015569881","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T00:14:46Z","timestamp":1422490486000},"page":"431-436","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Ethanol Lock Therapy"],"prefix":"10.1177","volume":"49","author":[{"given":"Rebecca F.","family":"Chhim","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA"},{"name":"Le Bonheur Children\u2019s Hospital, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M.","family":"Crill","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA"},{"name":"Le Bonheur Children\u2019s Hospital, Memphis, TN, USA"},{"name":"Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailey K.","family":"Collier","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis, TN, USA"},{"name":"Le Bonheur Children\u2019s Hospital, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra R.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Le Bonheur Children\u2019s Hospital, Memphis, TN, USA"},{"name":"Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massroor","family":"Pourcyrous","sequence":"additional","affiliation":[{"name":"Le Bonheur 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