{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:36:07Z","timestamp":1780439767872,"version":"3.54.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T00:00:00Z","timestamp":1427414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Background: Cyclosporine (CsA), which is used for graft-versus-host disease prophylaxis in allogeneic hematopoietic stem cell transplant (allo-HSCT), has a narrow therapeutic range and large interindividual and intraindividual pharmacokinetic variability. Nevertheless, population pharmacokinetic (PopPK) studies of CsA in allo-HSCT are scarce. Objective: The goal of our study was to build a PopPK model of CsA in allo-HSCT in consideration of demographic, clinical, and genetic polymorphisms data. Methods: A total of 34 adult allo-HSCT patients who received CsA were enrolled prospectively. Demographic, clinical, and CYP3A5 *1\/*3, CYP2C19 *1\/*2\/*3, ABCB1 3435C&gt;T, 1236C&gt;T, 2677G&gt;T\/A, ABCC2 -24C&gt;T, 1249G&gt;A, VDR Bsml, Apal polymorphisms data were collected. A PopPK modeling was conducted with NONMEM program. Results: A 1-compartment model with a 2-transit absorption compartment model was developed. After the stepwise covariate model building process, weight was incorporated into clearance (CL) as a power function model with the exponent value of 0.419. The final typical estimate of CL was 21.2 L\/h; volume of distribution was 430 L; logit-transformed bioavailability was 1.49 (bioavailability: 81%); and transit compartment rate was 2.87\/h. None of the genetic polymorphisms in CYP3A5, CYP2C19, ABCB1, ABCC2, and VDR were significant covariates in the pharmacokinetics of CsA. Conclusions: In our study, it was observed that weight had a significant effect on CL. Genetic polymorphisms did not affect CsA pharmacokinetics. Prospective studies with a larger number of participants is needed to validate the results of this study.<\/jats:p>","DOI":"10.1177\/1060028015577798","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T00:52:44Z","timestamp":1427590364000},"page":"622-630","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Population Pharmacokinetics of Cyclosporine in Hematopoietic Stem Cell Transplant Patients"],"prefix":"10.1177","volume":"49","author":[{"given":"Myeong Gyu","family":"Kim","sequence":"first","affiliation":[{"name":"Seoul National University, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Wha","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Seoul National University, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayoung","family":"Han","sequence":"additional","affiliation":[{"name":"Seoul National University, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwi-Yeol","family":"Yun","sequence":"additional","affiliation":[{"name":"Chungnam National University, College of Pharmacy, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonyang","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University, College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Mi","family":"Oh","sequence":"additional","affiliation":[{"name":"Seoul National University, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"bibr1-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705404"},{"key":"bibr2-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1258\/000456302320314430"},{"key":"bibr3-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2010.26"},{"key":"bibr4-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201323200"},{"key":"bibr5-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.39.1.361"},{"key":"bibr6-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1517\/phgs.4.4.397.22747"},{"key":"bibr7-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.127.209"},{"key":"bibr8-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328364db84"},{"key":"bibr9-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-8791(03)00076-4"},{"key":"bibr10-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb03950.x"},{"key":"bibr11-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181d5881f"},{"key":"bibr12-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0000000000000337"},{"key":"bibr13-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-007-9066-0"},{"key":"bibr14-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3180310f9d"},{"key":"bibr15-1060028015577798","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200645090-00003"},{"key":"bibr16-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1275-9"},{"key":"bibr17-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-012-0087-8"},{"key":"bibr18-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1097\/01.ftd.0000148448.51225.2c"},{"key":"bibr19-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181fb6ce3"},{"key":"bibr20-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200406000-00012"},{"key":"bibr21-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702375"},{"key":"bibr22-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.04116.x"},{"key":"bibr23-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702545"},{"key":"bibr24-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0959-2"},{"key":"bibr25-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.08.022"},{"key":"bibr26-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.6.790"},{"key":"bibr27-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R004"},{"key":"bibr28-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003253617"},{"key":"bibr29-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-013-0037-x"},{"key":"bibr30-1060028015577798","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050199"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028015577798","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028015577798","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028015577798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:43Z","timestamp":1777374943000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1060028015577798"}},"subtitle":["Consideration of Genetic Polymorphisms"],"short-title":[],"issued":{"date-parts":[[2015,3,27]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1177\/1060028015577798"],"URL":"https:\/\/doi.org\/10.1177\/1060028015577798","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,27]]}}}