{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:07:00Z","timestamp":1777421220917,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Background: Loop diuretics play a crucial role in symptom management in patients with fluid overload. There is a paucity of data regarding optimal diuretic dose at hospital discharge for acute decompensated heart failure (ADHF) patients requiring loop diuretics. Objective: To compare all-cause 30-day readmission in ADHF patients on chronic loop diuretics who had an increase in loop diuretic dose at discharge (relative to their preadmission dose) with patients without a change or a decrease in loop diuretic dose at discharge. Methods: This was a multicenter, retrospective cohort study. Institutional review board approval was obtained. Patients admitted with a primary discharge diagnosis of heart failure, evidence of fluid overload, and reduced ejection fraction were included. Patients were divided into 2 groups based on total daily loop diuretic dose at discharge: those discharged on an increased dose and those discharged on a dose less than or equal to their preadmission dose. Results: A total of 131 patient admissions met inclusion criteria; 50 had an increase in loop diuretic dose at discharge, and 81 were discharged with no change or a decrease in diuretic dose. Patients in the increased dose group had an all-cause 30-day readmission rate of 20% compared with 38% of patients with no change or a decrease in diuretic dose (adjusted odds ratio = 0.320; 95% CI = 0.117-0.873). Conclusion: In patients admitted for ADHF with reduced ejection fraction and evidence of fluid overload, an increase in loop diuretic dose at discharge was associated with a reduced rate of 30-day hospital readmission.<\/jats:p>","DOI":"10.1177\/1060028016637385","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T22:13:56Z","timestamp":1457475236000},"page":"437-445","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Discharge Diuretic Dose and 30-Day Readmission Rate in Acute Decompensated Heart Failure"],"prefix":"10.1177","volume":"50","author":[{"given":"Ashley E.","family":"Woodruff","sequence":"first","affiliation":[{"name":"State University of New York at Buffalo, NY, USA"},{"name":"Buffalo General Medical Center, Buffalo, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley M.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Lebanon Veterans Affairs Medical Center, Lebanon, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn A.","family":"Hempel","sequence":"additional","affiliation":[{"name":"State University of New York at Buffalo, NY, USA"},{"name":"Buffalo General Medical Center, Buffalo, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Buffalo General Medical Center, Buffalo, NY, USA"},{"name":"D\u2019Youville College, Buffalo, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"Echtenkamp","sequence":"additional","affiliation":[{"name":"Buffalo General Medical Center, Buffalo, NY, USA"},{"name":"D\u2019Youville College, Buffalo, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany K.","family":"Hassan","sequence":"additional","affiliation":[{"name":"D\u2019Youville College, Buffalo, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"bibr1-1060028016637385","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIR.0b013e3181cbbef1","volume":"121","author":"Lloyd-Jones D","year":"2010","journal-title":"Circulation"},{"key":"bibr2-1060028016637385","doi-asserted-by":"publisher","DOI":"10.1161\/HHF.0b013e318291329a"},{"key":"bibr3-1060028016637385","unstructured":"Centers for Medicare and Medicaid Services. 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