{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T17:52:11Z","timestamp":1782150731952,"version":"3.54.5"},"reference-count":19,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T00:00:00Z","timestamp":1471651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Objective: The purpose of this article is to describe the relationship between proton pump inhibitors (PPIs) and symptoms of myopathy based on case reports. Data Sources: A literature search was conducted in PubMed (1946 to June 2016) using MeSH terms proton pump inhibitors, omeprazole, esomeprazole, lansoprazole, dexlansoprazole, rabeprazole, pantoprazole, and muscular diseases. Additionally, a search was conducted in ToxNet and EMBASE using similar search criteria. Study Selection and Data Abstraction: The resulting articles were scanned to assess relevance to the review. Bibliographies of all relevant articles were evaluated for additional sources; 26 articles resulted from the search of PubMed, ToxNet, and EMBASE; articles that involved medications typically considered to have myalgia-like side effects (eg, statins), or included patients who presented with a confounding disease state (eg, Guillain-Barr\u00e9) were excluded. Data Synthesis: In total, 11 case reports as well as a review of an adverse event reporting database that included 292 cases were evaluated. Association of PPI use and myopathy symptoms does not have a clear etiology. Overall, the available published data do not show a high risk of myopathy with PPI use but should be considered if a patient presents with myopathy symptoms and concurrent PPI use. Conclusion: A limited body of published data suggests that PPI use has been associated with myopathy-like symptoms without long-term effects following discontinuation. Although myopathy is a rare adverse effect observed with PPIs, it can be a serious side effect to be considered when starting a patient on acid suppression therapy.<\/jats:p>","DOI":"10.1177\/1060028016665641","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T20:58:46Z","timestamp":1471553926000},"page":"66-71","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Proton Pump Inhibitors"],"prefix":"10.1177","volume":"51","author":[{"given":"Evan W.","family":"Colmenares","sequence":"first","affiliation":[{"name":"University of North Carolina Medical Center, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley L.","family":"Pappas","sequence":"additional","affiliation":[{"name":"University of North Carolina Medical Center, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,8,20]]},"reference":[{"key":"bibr1-1060028016665641","unstructured":"Food and Drug Administration. Prilosec OTC approval letter (June 2003). http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/appletter\/2003\/21229ltr_Prilosec.pdf. Accessed August 18, 2015."},{"key":"bibr2-1060028016665641","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13766"},{"key":"bibr3-1060028016665641","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2014.03.019"},{"key":"bibr4-1060028016665641","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.01.021"},{"key":"bibr5-1060028016665641","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G703"},{"key":"bibr6-1060028016665641","unstructured":"Wolters Kluwer Health, Inc. Drug facts and comparisons [database online]. http:\/\/online.factsandcomparisons.com\/index.aspx? Accessed May 26, 2015."},{"key":"bibr7-1060028016665641","unstructured":"Taber\u2019s\u00ae Cyclopedic Medical Dictionary\n                      . 22nd ed. Philadelphia, PA: F A Davis; 2013. http:\/\/www.tabers.com\/tabersonline\/. 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