{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:39:20Z","timestamp":1778773160135,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","award":["Frequency and Nature of Clinically Significant Dru"],"award-info":[{"award-number":["Frequency and Nature of Clinically Significant Dru"]}],"id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Background: HIV-infected patients receiving antiretroviral therapy (ART) are at risk for contraindicated drug-drug interactions (XDDIs). Objective: This study compared the frequency of XDDIs between different types of ART regimens. Methods: A retrospective cohort study was performed among adult HIV-infected patients receiving care at either the Upstate New York Veterans\u2019 Healthcare Administration or the University of New Mexico Truman Health Services between 2000 and 2013. The cohort consisted of patients receiving traditional ART regimens composed of 2 nucleoside reverse transcriptase inhibitors plus either a nonnucleoside reverse transcriptase inhibitor (NNRTI), a protease inhibitor (PI), or an integrase strand transfer inhibitor (INSTI). The primary outcome was the presence of XDDIs. Lexi-Interact was used to define XDDIs. Results: Of the 1329 patients who met inclusion criteria, 45.7%, 34.2%, and 20.1% were receiving an NNRTI-, PI-, or INSTI- based ART regimen, respectively. Among the 128 (9.6%) patients with an XDDI, more than half (53.9%) had an interaction involving ART. The presence of XDDIs was highest for PI-based regimens (16.3%) compared with INSTI- (7.9%) and NNRTI-based (5.4%) regimens; P &lt; 0.001. The variables independently associated with XDDIs were ART regimen type (prevalence ratio [PR] = 1.91; 95% CI = 1.51-2.40, P &lt; 0.001), use of \u22656 non-HIV medications (PR = 5.84; 95% CI = 3.92-8.71, P &lt; 0.001), and age \u226540 years (PR = 1.62; 95% CI = 0.92-2.86, P = 0.10). Conclusion: The probability of XDDIs varies as a function of ART regimen type, advanced age, and use of multiple non-HIV medications.<\/jats:p>","DOI":"10.1177\/1060028016685115","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T18:41:31Z","timestamp":1484851291000},"page":"365-372","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparing the Frequencies of Contraindicated Drug-Drug Interactions Between Differing Antiretroviral Regimens in HIV-Infected Patients"],"prefix":"10.1177","volume":"51","author":[{"given":"Bernadette","family":"Jakeman","sequence":"first","affiliation":[{"name":"University of New Mexico College of Pharmacy, Albuquerque, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Nasiri","sequence":"additional","affiliation":[{"name":"Albany College of Pharmacy and Health Sciences, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Ruth","sequence":"additional","affiliation":[{"name":"University of New Mexico College of Pharmacy, Albuquerque, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Morse","sequence":"additional","affiliation":[{"name":"Albany College of Pharmacy and Health Sciences, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheran","family":"Mahatme","sequence":"additional","affiliation":[{"name":"Stratton Veterans Affairs Medical Center, Albany, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimish","family":"Patel","sequence":"additional","affiliation":[{"name":"Albany College of Pharmacy and Health Sciences, NY, USA"},{"name":"Stratton Veterans Affairs Medical Center, Albany, NY, 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