{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:09:59Z","timestamp":1790179799624,"version":"4.1.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Background: Iron deficiency anemia (IDA) is common in children. Limited data exist on the efficacy and safety of ferumoxytol in children. Objective: To assess the efficacy of 10 mg\/kg dose given over 15-60 minutes in correcting IDA and report any adverse drug reactions (ADRs). Methods: We conducted a retrospective review of all patients who received ferumoxytol infusions for the management of IDA by the Pediatric Blood Management Program between October 2010 and March 2015. Results: A total of 110 infusions were given to 54 patients. Compared with baseline preinfusion hemoglobin (Hb; 9.2 \u00b1 1.9 g\/dL), a significant rise was seen at 1 week and 4 weeks postinfusion (11.5 \u00b1 1.5 and 11.8 \u00b1 1.7 g\/dL, respectively, P &lt; 0.001). Also, a significant rise in serum ferritin at 1 week and 4 weeks postinfusion was seen (51 \u00b1 71 vs 192 \u00b1 148 and 89 \u00b1 135 ng\/mL, P &lt; 0.001 and &lt;0.035, respectively). Patients who concomitantly received erythropoietin had a significantly larger Hb rise from baseline than those who did not at 4 weeks (2.7 \u00b1 2.2 vs 1.6 \u00b1 1.1 g\/dL, P &lt; 0.017). ADRs included pruritus (n = 1), urticaria (n = 1), and multisymptom episodes (n = 3) that included shortness of breath, chest tightness, back pain, and epigastric cramping that responded to therapy with IV diphenhydramine and methylprednisolone. Conclusion: Ferumoxytol was effective in treating IDA in our small study. Slow infusion rate and close monitoring allowed early detection of the infrequent ADRs.<\/jats:p>","DOI":"10.1177\/1060028017699429","type":"journal-article","created":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T08:54:06Z","timestamp":1489395246000},"page":"548-554","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":36,"title":["Intravenous Ferumoxytol in Pediatric Patients With Iron Deficiency Anemia"],"prefix":"10.1177","volume":"51","author":[{"given":"Nabil","family":"Hassan","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital of Illinois at OSF St Frances, Peoria, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Boville","sequence":"additional","affiliation":[{"name":"Helen Devos Children\u2019s Hospital, Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diann","family":"Reischmann","sequence":"additional","affiliation":[{"name":"Grand Valley State University, Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akunne","family":"Ndika","sequence":"additional","affiliation":[{"name":"Grand Rapids Medical Education Partners, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sterken","sequence":"additional","affiliation":[{"name":"Helen Devos Children\u2019s Hospital, Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Kovey","sequence":"additional","affiliation":[{"name":"Parkview Regional Medical Center, Fort Wayne, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"key":"bibr1-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jju009"},{"key":"bibr2-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-14-184"},{"key":"bibr3-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2011.12.001"},{"key":"bibr4-1060028017699429","first-page":"B4824","volume":"61","author":"Bager P.","year":"2014","journal-title":"Dan Med J"},{"key":"bibr5-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21740"},{"key":"bibr6-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.081"},{"key":"bibr7-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.06.079"},{"key":"bibr8-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307153290308"},{"key":"bibr9-1060028017699429","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00585"},{"key":"bibr10-1060028017699429","doi-asserted-by":"publisher","DOI":"10.4103\/0976-9668.127317"},{"key":"bibr11-1060028017699429","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1745.97619"},{"key":"bibr12-1060028017699429","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i13.3542"},{"key":"bibr13-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25752"},{"key":"bibr14-1060028017699429","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20110123"},{"key":"bibr15-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007101156"},{"key":"bibr16-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.08.001"},{"key":"bibr17-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00598.x"},{"key":"bibr18-1060028017699429","doi-asserted-by":"publisher","DOI":"10.1159\/000087212"},{"key":"bibr19-1060028017699429","unstructured":"Feraheme\u2122 (ferumoxytol) injection [package insert]. 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