{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:55:26Z","timestamp":1777420526682,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100014569","name":"Sociedad Espa\u00f1ola de Farmacia Hospitalaria","doi-asserted-by":"crossref","award":["15.000"],"award-info":[{"award-number":["15.000"]}],"id":[{"id":"10.13039\/501100014569","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>Background: HIV+ patients have increased their life expectancy with a parallel increase in age-associated comorbidities. Objective: To determine the effectiveness of an intensive pharmaceutical care follow-up program in comparison to a traditional model among HIV-infected patients with moderate\/high cardiovascular risk. Method: This was a multicenter, prospective, randomized study of a structured health intervention conducted between January-2014 and June-2015 with 12 months of follow-up at outpatient pharmacy services. The selected patients were randomized to a control group (usual care) or intervention group (intensive pharmaceutical care). The interventional program included follow-up of all medication taken by the patient to detect and work toward the achievement of pharmacotherapeutic objectives related to cardiovascular risk and making recommendations for improving diet, exercising, and smoking cessation. Individual motivational interview and periodic contact by text messages about health promotion were used. The primary end point was the percentage of patients who had reduced the cardiovascular risk index, according to the Framingham-score. Results: A total of 53 patients were included. As regards the main variable, 20.7% of patients reduced their Framingham-score from high\/very high to moderate\/low cardiovascular risk versus 12.5% in the control group ( P=0.016). In the intervention group, the number of patients with controlled blood pressure increased by 32.1% ( P=0.012); 37.9% of patients overall stopped smoking ( P=0.001), and concomitant medication adherence increased by 39.4% at the 48-week follow-up ( P=0.002). Conclusion and Relevance: Tailored pharmaceutical care based on risk stratification, motivational interviewing, and new technologies might lead to improved health outcomes in HIV+ patients at greater cardiovascular risk.<\/jats:p>","DOI":"10.1177\/1060028018778045","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T05:58:56Z","timestamp":1527573536000},"page":"1098-1108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Effect of a Structured Pharmaceutical Care Intervention Versus Usual Care on Cardiovascular Risk in HIV Patients on Antiretroviral Therapy: INFAMERICA Study"],"prefix":"10.1177","volume":"52","author":[{"given":"Ram\u00f3n","family":"Morillo-Verdugo","sequence":"first","affiliation":[{"name":"Valme Hospital, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3357-5954","authenticated-orcid":false,"given":"Mar\u00eda de las Aguas","family":"Robustillo-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Valme Hospital, Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Teresa","family":"Mart\u00edn-Conde","sequence":"additional","affiliation":[{"name":"Clinic Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gador","family":"Callej\u00f3n-Callej\u00f3n","sequence":"additional","affiliation":[{"name":"Nuestra Se\u00f1ora de Candelaria Hospital, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3227-8002","authenticated-orcid":false,"given":"Purificaci\u00f3n","family":"Cid-Silva","sequence":"additional","affiliation":[{"name":"A Coru\u00f1a Hospital Complex, A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Moriel-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Mostoles Hospital, Mostoles, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Tortajada-Goitia","sequence":"additional","affiliation":[{"name":"Costa del Sol Hospital, Marbella, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8202-0790","authenticated-orcid":false,"given":"Carmen Victoria","family":"Almeida-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Seville University, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"bibr1-1060028018778045","unstructured":"Grupo de expertos de la Secretar\u00eda del Plan Nacional sobre el SIDA (SPNS), Sociedad Espa\u00f1ola de Geriatr\u00eda y Gerontolog\u00eda (SEGG). Documento de consenso sobre edad avanzada e infecci\u00f3n por el virus de la inmunodeficiencia humana. 2015. https:\/\/www.msssi.gob.es\/en\/ciudadanos\/enfLesiones\/enfTransmisibles\/sida\/publicaciones\/profSanitarios\/docEdadAvanzadaVIH.pdf"},{"key":"bibr2-1060028018778045","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-015-0284-6"},{"key":"bibr3-1060028018778045","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-016-0331-y"},{"key":"bibr4-1060028018778045","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2016.02.008"},{"key":"bibr5-1060028018778045","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-016-0105-z"},{"key":"bibr6-1060028018778045","doi-asserted-by":"publisher","DOI":"10.5501\/wjv.v4.i2.56"},{"key":"bibr7-1060028018778045","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00056-0"},{"key":"bibr8-1060028018778045","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2014.06.006"},{"key":"bibr9-1060028018778045","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12253"},{"key":"bibr10-1060028018778045","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp150623"},{"key":"bibr11-1060028018778045","doi-asserted-by":"publisher","DOI":"10.7399\/fh.2016.40.6.10567"},{"key":"bibr12-1060028018778045","doi-asserted-by":"publisher","DOI":"10.1157\/13043951"},{"key":"bibr13-1060028018778045","unstructured":"Pharmaceutical Care Research Group, University of Granada (Spain). Pharmacotherapy follow-up: the Dader method (3rd revision: 2005). http:\/\/pharmacypractice.org\/journal\/index.php\/pp\/article\/viewFile\/300\/289. Accessed March 7, 2017."},{"key":"bibr14-1060028018778045","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-016-0387-1"},{"key":"bibr15-1060028018778045","unstructured":"Codina C, Delgado O. Recomendaciones para desarrollar un programa de atenci\u00f3n farmac\u00e9utica al paciente VIH. https:\/\/www.sefh.es\/normas\/Paciente_VIH.pdf. Accessed April 22, 2018."},{"key":"bibr16-1060028018778045","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S30244"},{"key":"bibr17-1060028018778045","unstructured":"Glesby MJ. Cardiovascular complications of HIV infection. Top Antivir Med. 2017;24:127-131. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28208120. 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