{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:56:58Z","timestamp":1777420618369,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1P50HL10584\u201301"],"award-info":[{"award-number":["1P50HL10584\u201301"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Background: Racial disparities in blood pressure (BP) control persist, but whether differences by race in antihypertensive medication intensification (AMI) contribute is unknown. Objective: To compare AMI by race for patients with elevated home BP readings. Methods: This prospective cohort study followed adult patients from 6 rural primary care practices who used home BP monitoring (HBPM) and recorded\/reported values. For providers, AMI was encouraged when mean HBPM systolic blood pressure (SBP) values were \u2a7e135 mm Hg; patients received phone-based coaching on HBPM technique and sharing HBPM findings. AMI was assessed between baseline and 12 months using defined daily dose (DDD) and summed to create a total antihypertensive DDD value. Results: A total of 217 patients (mean age = 61.4 \u00b1 10.2 years; 66% female; 57% black) provided usable HBPM data. Among 90 (41%) intensification-eligible hypertensive patients (ie, mean HBPM SBP values for 6-months \u2a7e135 mm Hg), mean total antihypertensive DDD was increased in 61% at 12 months. Blacks had significantly higher mean DDD at baseline and 12 months, but intensification (+0.72 vs +0.65; P = 0.83) was similar by race. However, intensification was greater in males than females (+1.1 vs +0.39; P = 0.031). Reduction in mean SBP following intensification was greater in white versus black patients (\u22128.2 vs \u22123.9 mm Hg; P = 0.14). Conclusion\/Relevance: Treatment intensification in HBPM users was similar by race, differed significantly by gender, and may produce a greater response in white patients. Differential AMI in HBPM users does not appear to contribute to persistent racial disparities in BP control.<\/jats:p>","DOI":"10.1177\/1060028018806001","type":"journal-article","created":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T01:41:43Z","timestamp":1538617303000},"page":"333-340","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Race-Specific Patterns of Treatment Intensification Among Hypertensive Patients Using Home Blood Pressure Monitoring: Analysis Using Defined Daily Doses in the Heart Healthy Lenoir Study"],"prefix":"10.1177","volume":"53","author":[{"given":"Doyle M.","family":"Cummings","sequence":"first","affiliation":[{"name":"East Carolina University, Greenville, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Adams","sequence":"additional","affiliation":[{"name":"East Carolina University, Greenville, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacquie","family":"Halladay","sequence":"additional","affiliation":[{"name":"University of North Carolina\u2014Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Hinderliter","sequence":"additional","affiliation":[{"name":"University of North Carolina\u2014Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4075-2875","authenticated-orcid":false,"given":"Katrina E.","family":"Donahue","sequence":"additional","affiliation":[{"name":"University of North Carolina\u2014Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crystal W.","family":"Cene","sequence":"additional","affiliation":[{"name":"University of North Carolina\u2014Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quefeng","family":"Li","sequence":"additional","affiliation":[{"name":"University of North Carolina\u2014Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassandra","family":"Miller","sequence":"additional","affiliation":[{"name":"University of North Carolina\u2014Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly","family":"Garcia","sequence":"additional","affiliation":[{"name":"University of North Carolina\u2014Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Tillman","sequence":"additional","affiliation":[{"name":"Open Water Consulting, Cape Carteret, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Little","sequence":"additional","affiliation":[{"name":"Kinston Medical Specialists, Pink Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"DeWalt","sequence":"additional","affiliation":[{"name":"University of North Carolina\u2014Chapel Hill, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"bibr1-1060028018806001","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"bibr2-1060028018806001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"bibr3-1060028018806001","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2981"},{"key":"bibr4-1060028018806001","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460240051027"},{"key":"bibr5-1060028018806001","doi-asserted-by":"publisher","DOI":"10.1007\/s12170-015-0446-5"},{"key":"bibr6-1060028018806001","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu233"},{"key":"bibr7-1060028018806001","unstructured":"Million Hearts. 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