{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:03:41Z","timestamp":1781877821999,"version":"3.54.5"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T00:00:00Z","timestamp":1540944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>\n                    Background: Oral anti-Xa inhibitors have demonstrated noninferiority to vitamin K antagonists (VKAs) for the prevention of stroke in patients with atrial fibrillation and recurrent venous thromboembolism. They are associated with a decrease in major bleeding. In contrast with VKA, no coagulation monitoring is required. However, in clinical practice, determination of drug concentration is sometimes necessary. Objective: The objective of this study was to evaluate a low-molecular-weight heparin (LMWH) calibrated anti-Xa assay for the quantification of rivaroxaban and apixaban plasma concentration in emergency. Methods: The anti-Xa plasma concentration of rivaroxaban and apixaban were measured in emergency in 210 patients using STA anti-Xa liquid assay. For each plasma concentration &lt;150 ng\/mL of rivaroxaban or apixaban, an anti-Xa assay calibrated with LMWH was performed. Results: We demonstrated a significant correlation between LMWH anti-Xa activity and rivaroxaban ( R\n                    <jats:sup>2<\/jats:sup>\n                    = 0.947) or apixaban ( R\n                    <jats:sup>2<\/jats:sup>\n                    = 0.959) concentration and a significant correlation between rivaroxaban and apixaban plasma concentration ( R\n                    <jats:sup>2<\/jats:sup>\n                    = 0.972). A LMWH anti-Xa activity &lt;0.50 IU\/mL could exclude a plasma concentration of rivaroxaban and apixaban &gt;30 ng\/mL and indicate the feasibility of invasive procedure. Conclusion and Relevance: In the absence of a specific test, LMWH-calibrated anti-Xa assay could be used to determine the presence and evaluate the plasma concentration of oral anti-Xa inhibitors. However, these initial findings require confirmation using other chromogenic calibrated oral anti-Xa assays.\n                  <\/jats:p>","DOI":"10.1177\/1060028018811657","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T07:15:55Z","timestamp":1540970155000},"page":"341-347","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Anti-Xa Oral Anticoagulant Plasma Concentration Assay in Real Life: Rivaroxaban and Apixaban Quantification in Emergency With LMWH Calibrator"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-7713","authenticated-orcid":false,"given":"Paul","family":"Billoir","sequence":"first","affiliation":[{"name":"Rouen University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Barbay","sequence":"additional","affiliation":[{"name":"Rouen University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc Marie","family":"Joly","sequence":"additional","affiliation":[{"name":"Rouen University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Fresel","sequence":"additional","affiliation":[{"name":"Rouen University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie H\u00e9l\u00e8ne","family":"Chr\u00e9tien","sequence":"additional","affiliation":[{"name":"Rouen University Hospital, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Le Cam Duchez","sequence":"additional","affiliation":[{"name":"Rouen University Hospital, 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