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Six patients had potential discoloration, but studies consistently found no difference in tooth discoloration between exposed patients and controls. Recommendations have changed stating doxycycline, but not other tetracyclines, can be used for short courses (&lt;21 days) regardless of age. Clinicians should be aware of these data because doxycycline use may extend to disease states apart from tick-borne illnesses in pediatric patients.<\/jats:p>","DOI":"10.1177\/1060028019863796","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:53:12Z","timestamp":1562547192000},"page":"1162-1166","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":49,"title":["Doxycycline and Tooth Discoloration in Children: Changing of Recommendations Based on Evidence of Safety"],"prefix":"10.1177","volume":"53","author":[{"given":"Jeremy S.","family":"Stultz","sequence":"first","affiliation":[{"name":"University of Tennessee Health Science Center College of Pharmacy, Memphis, TN, USA"},{"name":"Le Bonheur Children\u2019s Hospital, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7873-3157","authenticated-orcid":false,"given":"Lea S.","family":"Eiland","sequence":"additional","affiliation":[{"name":"Auburn University Harrison School of Pharmacy, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,7,7]]},"reference":[{"key":"bibr1-1060028019863796","unstructured":"Doxycycline hyclate [package insert]. 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