{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:59:25Z","timestamp":1777420765060,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T00:00:00Z","timestamp":1565827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Background: After stabilization with intravenous (IV) antihypertensives, the impact of speed-of-transition from IV to enteral (PO) medications in the intensive care unit (ICU) is unknown. Objective: To assess ICU length of stay (LOS) based on transition time from IV to PO antihypertensive therapy. Methods: Retrospective study of aortic dissection patients admitted from June 2013 to July 2017 at a tertiary teaching hospital. Patients were grouped based on achieving full transition to PO medications in either \u226472 hours or &gt;72 hours from the first PO dose. Secondary end points included hospital LOS, IV infusion volume, medication cost, and time spent with arterial\/central lines. Results: A total of 56 patients transitioned completely from IV to PO therapy in \u226472 hours, and 72 patients required more than 72 hours. Demographics, IV and PO medication choices, and timing of first PO medication administration were similar between groups. ICU LOS was shorter in the group transitioned in \u226472 hours compared with those who took longer to transition (3.6 vs 10.5 days; P &lt; 0.001). Hospital LOS, IV infusion volume, and cost were also significantly lower in the \u226472-hour group ( P &lt; 0.001). The rapid transition group also spent less time with arterial lines (44 vs 156 hours, P &lt; 0.001) and central lines (45 vs 242 hours, P &lt; 0.001). Conclusion and Relevance: In this cohort, transitioning to PO antihypertensives in \u226472 hours was associated with shorter ICU LOS and improvement in other measured outcomes. These observational data are the first to describe a potentially critical juncture in postdissection care; a prospective study is warranted.<\/jats:p>","DOI":"10.1177\/1060028019870181","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T02:55:58Z","timestamp":1565924158000},"page":"22-28","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Faster Transition From Intravenous to Oral Antihypertensives Associated With Improved Outcomes After Aortic Dissection"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-5293","authenticated-orcid":false,"given":"Christopher J.","family":"Michaud","sequence":"first","affiliation":[{"name":"Spectrum Health, Fred and Lena Meijer Heart Center, Grand Rapids, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E.","family":"Packard","sequence":"additional","affiliation":[{"name":"Spectrum Health, Fred and Lena Meijer Heart Center, Grand Rapids, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Timek","sequence":"additional","affiliation":[{"name":"Spectrum Health, Fred and Lena Meijer Heart Center, Grand Rapids, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,8,15]]},"reference":[{"key":"bibr1-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181d4739e"},{"key":"bibr2-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d8290"},{"key":"bibr3-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000597"},{"key":"bibr4-1060028019870181","first-page":"694","volume":"38","author":"Criado FJ","year":"2011","journal-title":"Tex Heart Inst J"},{"key":"bibr5-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.006320"},{"key":"bibr6-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2013.07.011"},{"key":"bibr7-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1P086"},{"key":"bibr8-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.08.012"},{"key":"bibr9-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12024"},{"key":"bibr10-1060028019870181","first-page":"1732","volume-title":"Textbook of Critical Care","volume":"2005","author":"Dasta JF","edition":"5"},{"key":"bibr11-1060028019870181","doi-asserted-by":"publisher","DOI":"10.2165\/0003495-200868170-00005"},{"key":"bibr12-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.21.2585"},{"key":"bibr13-1060028019870181","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5151.164940"},{"key":"bibr14-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1007\/BF01745243"},{"key":"bibr15-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1186\/cc6149"},{"key":"bibr16-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1177\/0885066610394322"},{"key":"bibr17-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.02.010"},{"key":"bibr18-1060028019870181","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeq025"}],"container-title":["Annals of Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028019870181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1060028019870181","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1060028019870181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:15:09Z","timestamp":1777374909000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1060028019870181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,15]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1177\/1060028019870181"],"URL":"https:\/\/doi.org\/10.1177\/1060028019870181","relation":{},"ISSN":["1060-0280","1542-6270"],"issn-type":[{"value":"1060-0280","type":"print"},{"value":"1542-6270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,15]]}}}