{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:04:50Z","timestamp":1783721090365,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ann Pharmacother"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Background: The use of extracorporeal membrane oxygenation (ECMO) sometimes requires deep levels of sedation (Richmond Agitation Sedation Scale [RASS] \u22125) in patients with acute respiratory distress syndrome (ARDS). The role of obesity in opioid and sedative requirements remains unclear in patients receiving ECMO. Objective: This study sought to determine whether obesity increases midazolam and opioid requirements in patients receiving venovenous (vv)-ECMO up to the first 7 days after initiation. Methods: This was a retrospective cohort study of adult patients with ARDS managed with vv-ECMO. Results: The obese (n = 38) and nonobese (n = 43) groups had similar baseline characteristics. Fentanyl equivalents were significantly higher on day 3 in the obese group ( P = 0.02) despite similar RASS scores with no differences in midazolam requirements. There were no differences in duration of ECMO, length of stay, or mortality. Conclusion and Relevance: Daily midazolam requirements were not significantly different, and opioid requirements were only significantly higher in the obese group on day 3 despite similar levels of sedation. The impact of obesity with the addition of ECMO and how to adapt doses of medications remains elusive.<\/jats:p>","DOI":"10.1177\/1060028019872940","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T05:16:30Z","timestamp":1566882990000},"page":"144-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Opioid and Benzodiazepine Requirements in Obese Adult Patients Receiving Extracorporeal Membrane Oxygenation"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2435-0817","authenticated-orcid":false,"given":"Brittany S.","family":"Verkerk","sequence":"first","affiliation":[{"name":"NewYork-Presbyterian Hospital, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1527-6830","authenticated-orcid":false,"given":"Amy L.","family":"Dzierba","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Muir","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Der-Nigoghossian","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Brodie","sequence":"additional","affiliation":[{"name":"NewYork-Presbyterian Hospital, New York, NY, USA"},{"name":"Columbia College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Bacchetta","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Rietdijk","sequence":"additional","affiliation":[{"name":"University Medical Center Rotterdam, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bakker","sequence":"additional","affiliation":[{"name":"Columbia College of Physicians and Surgeons, New York, NY, USA"},{"name":"University Medical Center Rotterdam, Rotterdam, Netherlands"},{"name":"NYU Langone Department of Pulmonology and Critical Care, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"bibr1-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61069-2"},{"key":"bibr2-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct1103720"},{"key":"bibr3-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3182904a52"},{"key":"bibr4-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1204000411"},{"key":"bibr5-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182783b72"},{"key":"bibr6-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000658"},{"key":"bibr7-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2012.02.013"},{"key":"bibr8-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1644-y"},{"key":"bibr9-1060028019872940","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1177\/0310057X1204000411","volume":"40","author":"Shekar K","year":"2012","journal-title":"Anaesth Intensive Care"},{"key":"bibr10-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.07.020"},{"key":"bibr11-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1760"},{"key":"bibr12-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4519-9"},{"key":"bibr13-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001484"},{"key":"bibr14-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1186\/cc11679"},{"key":"bibr15-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0772-5"},{"key":"bibr16-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0891-z"},{"key":"bibr17-1060028019872940","doi-asserted-by":"publisher","DOI":"10.1177\/0267659112456894"},{"key":"bibr18-1060028019872940","doi-asserted-by":"publisher","DOI":"10.2165\/11319970-000000000-00000"},{"key":"bibr19-1060028019872940","unstructured":"Centers for Disease Control and Prevention. 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